Peptides9 min read
Pemvidutide and MASH: what the IMPACT liver biopsies showed
IMPACT showed a MASH-resolution signal at 24 weeks, while its primary fibrosis comparison remained inconclusive. Later tests answer different questions.
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Research, explained. Explore peptides, supplements, hormone health, longevity and red light therapy with clear, practical breakdowns of what the studies actually tell us.
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HRT8 min read
Vaginal Estrogen and Systemic HRT: Why the Distinction Changes the Discussion
Low-dose local estrogen and systemic HRT have different purposes, exposure and safety questions—even when both come as vaginal rings.
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HRT9 min read
HRT is not contraception: the perimenopause detail that gets missed
HRT can relieve menopause symptoms without preventing pregnancy. Understand contraception, uterine protection, bleeding changes and safe transitions.
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Peptides8 min read
Retatrutide and sensitive skin: how trials describe dysesthesia
Retatrutide trials report unpleasant skin sensations, but a symptom label is not a diagnosis of nerve damage. Here is what the data and terminology mean.
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Peptides9 min read
The case for following amylin drugs beyond the GLP-1 headlines
Amylin research offers a distinct biological approach and several clinical strategies. The evidence depends on the exact drug, combination and population.
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Peptides9 min read
Petrelintide tolerability: what the trials actually show
Early petrelintide studies reported mostly mild symptoms. The larger phase 2 publication adds a more detailed, and more qualified, safety picture.
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Peptides9 min read
Zenagamtide tablets and injections: what changes with the formulation?
Zenagamtide has real tablet and injection programs. Their absorption, diabetes results and longer obesity studies answer different questions.
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Peptides9 min read
PT-141 approval: who bremelanotide is actually for
What acquired, generalized HSDD means, who was studied, and why bremelanotide approval does not extend to every sexual-health claim.
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Peptides8 min read
PT-141 and blood pressure: why a temporary rise matters
Bremelanotide's pressure effect can be brief yet clinically relevant. Understand its timing, ambulatory measurements, contraindications and practical monitoring.
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Peptides9 min read
Oxytocin and autism: what the larger trials changed
Small positive studies led to larger trials that tempered the treatment claim. Outcomes, subgroups, and meaningful goals all matter.
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Peptides8 min read
The 2026 DSIP debate: what the FDA discussion can tell you about sleep
The FDA's 2026 emideltide discussion concerned compounding ingredients and evidence gaps, not a new demonstration that DSIP treats insomnia.
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Peptides9 min read
Afamelanotide for EPP: a treatment for painful light sensitivity
Afamelanotide can improve painful light sensitivity in EPP. Learn what the trials measured, their limitations and why the findings do not endorse tanning products.
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