Selank: The Definitive Guide

The Russian nasal-drop dose, the spray and injection schedules people use, what the anxiety trials found, and what users report.

See typical protocols

Selank at a glance.

Selank at a glance. Selank is a lab-made chain of seven amino acids, Thr-Lys-Pro-Arg-Pro-Gly-Pro: the immune peptide tuftsin with a Pro-Gly-Pro tail added. Formula C33H57N11O9, 751.9 g/mol, synthetic. How researchers think it works, from laboratory and animal studies and not proven in people: in binding tests it made GABA bind its receptor more strongly; in human blood samples it slowed enzymes that break down enkephalins; it eased anxious behaviour in a high-anxiety mouse strain. Discussed for anxiety, stress, sleep when anxiety is the problem, and calm focus. Typical labeled dose: 0.15% nose drops, 2 drops per nostril 3 times a day, about 900 mcg a day, for 14 days; the anxiety trials used 2,700 mcg a day. Human evidence: three small Russian trials against tranquilizers, none placebo-controlled or reported as blinded. Status: non-prescription drops in Russia, not FDA-approved, not named on the WADA 2026 or 2027 lists.

Selank

A lab-made peptide built from tuftsin, a small immune-system peptide, with a Pro-Gly-Pro tail added to slow its breakdown

Also called TP-7 or TKPRPGP · Селанк in Russian

Not the same as N-acetyl Selank amidate, Semax or tuftsin itself

7 amino acids C₃₃H₅₇N₁₁O₉ 751.9 g/mol Synthetic

T, Thr, position 1, polar, has a hydroxyl group
K, Lys, position 2, basic, positively charged
P, Pro, position 3, proline
R, Arg, position 4, basic, positively charged
P, Pro, position 5, proline
G, Gly, position 6, small, the smallest amino acid
P, Pro, position 7, proline

Positions 1 to 4 are tuftsin, Thr-Lys-Pro-Arg; positions 5 to 7 are an added Pro-Gly-Pro tail.

Bead positions show order, not 3D structure.

Basic(positively charged): Lys, Arg
Polar:Thr
Proline:Pro
Small:Gly

How researchers think it works

In laboratory and animal studies, not proven in people

GABA receptors
In binding tests, it made the calming messenger GABA bind its receptor more strongly.
Laboratory study
Enkephalin breakdown
In human blood samples in a dish, it slowed enzymes that break down calming enkephalins.
Laboratory study (human serum)
Calmer anxious mice
It eased anxious behaviour in a high-anxiety mouse strain, but not in calm mice.
Animal study

Discussed for

Anxiety and stress; sleep when anxiety is the problem; calm focus (often with Semax)

Typical labeled dose

2 drops per nostril0.15% nose drops, 3 times a day (about 900 mcg a day), for 14 days

Russian label; the anxiety trials used 2,700 mcg/day

Human evidence

3 small Russian trialsagainst tranquilizers, 60–70 patients each

No placebo; none reported blinding; all nose drops

Status

Non-prescription drops in Russia
Not FDA-approved
Not named on the WADA 2026 or 2027 lists

Conceptual summary: bead positions show amino-acid order, not a 3D structure. The calming-system and enzyme findings come from rat, mouse and laboratory studies; the human treatment studies gave Selank as nose drops, almost all to Russian patients with anxiety disorders.

Published by DoserlyUpdated September 26, 2026Next scheduled review: December 202641 min readHow this guide was made

In this guide

Key takeaways

What it is: a lab-made chain of seven amino acids built from tuftsin, a small immune-system peptide, with three amino acids added to make it last longer. It is sold in Russia as non-prescription nasal drops for anxiety and is not approved in the United States.
Typical protocol: the Russian label gives 2 drops in each nostril 3 times a day for 14 days, about 900 mcg a day, repeated after 1–3 weeks if needed; the anxiety trials used three times that, 2,700 mcg a day. Online, spray pages most often give 250–500 mcg one to three times a day, and injection pages 250–500 mcg by subcutaneous injection (into the fatty layer under the skin) once a day, usually for 2–4 weeks.
Route and half-life: every human treatment study gave Selank as intranasal drops (into the nose). Injections are common online but have never been tested as a treatment in people, and Selank's half-life in people has never been measured; in rats the intact peptide lasted only 7–10 minutes in the blood. See how route changes exposure.
Evidence: small Russian trials in people with anxiety disorders, open-label or with no reported blinding. Selank eased anxiety about as much as the tranquilizer medazepam in one, was weaker than phenazepam after two weeks in another, and had more responders than phenazepam a week after both were stopped. No placebo-controlled trial of its effects on symptoms has been published.
Safety: short courses of the licensed drops caused few and mild problems in trials, mainly a dry nose and occasional memory or concentration complaints, with no sedation. The label lists allergic reactions and a bad taste. People online also describe drowsiness, irritability, vivid dreams and, less often, anxiety that gets worse instead of better.
Important cautions: do not stop or cut back prescribed antidepressants, benzodiazepines or other psychiatric medicines to try Selank; it has never been tested as a replacement, and stopping some of them suddenly is dangerous. The label rules it out under 18 and in pregnancy and breastfeeding. Home-made sprays and injections have no human safety data, N-acetyl Selank amidate is a different molecule, and drop, spray and syringe-unit mix-ups are common, so check amounts with the calculator.
Legal status: not FDA-approved and not on the list of ingredients US pharmacies may compound; the FDA lists safety concerns for compounded Selank. Named in Canadian warnings about unauthorized injectable peptides; not named on the anti-doping list.

Jump to protocols · Risks and legal status · Common questions

What is Selank?

Selank is a lab-made peptide, a short chain of seven amino acids, sold in Russia as a non-prescription nasal-drop medicine for anxiety, nervous exhaustion and stress-related problems. Online it is popular as a "calm focus" peptide and is often paired with its sister peptide, Semax. [1], [2]

It was developed in Moscow by the Institute of Molecular Genetics and the Zakusov Institute of Pharmacology. The starting point was tuftsin, a natural four-amino-acid peptide (Thr-Lys-Pro-Arg) that acts on immune cells. The developers added three amino acids (Pro-Gly-Pro) to slow its breakdown, giving Thr-Lys-Pro-Arg-Pro-Gly-Pro, or TKPRPGP. Its development code was TP-7, its formula as a free peptide is C33H57N11O9 (751.9 g/mol), and the medicine uses it as an acetate salt. [3], [4], [5], [6], [7]

Selank is a registered medicine in Russia: 0.15% nasal drops, registered in 2009 and available without a prescription since 2017. It is investigational elsewhere: not approved by the US Food and Drug Administration (FDA), and we found no approval in Canada, Australia, the United Kingdom or the European Union. Its human research is almost entirely Russian and comes largely from the developers' network. [5], [2], [8], [9], [10], [11], [12]

Some websites say Selank could never be patented. It was: as an anxiety medicine in Russia in 1999, followed by Russian patents for other uses based on animal work. [6], [13], [14]

Typical Selank Protocols

Intranasal drops (into each nostril) · licensed Selank 0.15% (1.5 mg per mL; about 75 mcg per drop by the original instruction) · Amounts in micrograms (mcg) · Russian label and trials [1], [15], [16], [17]
Source	Amount each time	Frequency	Total per day	Course
Current Russian label (2025)	2 drops in each nostril (about 300 mcg)	3 times a day	About 900 mcg	14 days; may be repeated after 1–3 weeks
Original label (2009)	300–900 mcg (4–12 drops, no more than 2–3 per nostril at once, repeated after 15 minutes)	3 times a day	900–2,700 mcg	10–14 days; may be repeated after 1–3 weeks
Anxiety trials (2008–2015)	900 mcg (12 drops) in the 2008 trial; the later trials give only the daily total	3 times a day (2008 trial)	2,700 mcg	14 days Adults with anxiety disorders, compared with tranquilizers [16], [17], [18]

On the current label, each dose is 2 drops in each nostril, 3 times a day, for 14 days, which works out to about 900 mcg a day; the course can be repeated after 1–3 weeks. The label does not state the drop size; the microgram figures use the original instruction's 75 mcg per drop. The anxiety trials used the top of the older label range, 2,700 mcg a day. [1], [15], [16]

What doses do research nasal sprays use?

Outside Russia, most people use a spray mixed from a research-grade powder, or a ready-made spray, not the licensed drops. These schedules come from protocol websites.

Home-made or ready-made intranasal spray · Selank alone · Amounts in micrograms (mcg) · Each row is one source's complete schedule: low [19], mid [20], high [21]
Example	Amount each time	Frequency	Total per day	Duration
Low	200–300 mcg to start, then 300–500 mcg a day in total	Once or twice a day	300–500 mcg (stated maximum 600–800)	4–8 weeks, then a 2–4-week break
Mid	300 mcg	2–3 times a day	600–900 mcg	10–14 days on, then 7–10 days off
High	The daily amount split into 2–3 sprays	2–3 times a day	600–2,700 mcg	14–21 days on, then 1–3 weeks off

Spray pages most often give 250–500 mcg each time, one to three times a day (250–1,500 mcg a day), with courses from one week to a month. That ranges from well below to above the label's 900 mcg and stays below the 2,700 mcg used in the trials. [22], [23]

What doses are used for Selank injections?

Subcutaneous injection (into the fatty layer under the skin) · Selank alone · Amounts in micrograms (mcg) · No human study has tested this route · Each row is one source's complete schedule: low [24], mid [25], high [26]
Example	Amount each time	Frequency	Total per day	Duration
Low	100–300 mcg	Once daily	100–300 mcg	1 month on, 1 month off
Mid	250–500 mcg	Once daily, in the morning	250–500 mcg	2–4 weeks, then a break of the same length
High	250–500 mcg	1–3 times a day	250–1,500 mcg	2–4 weeks, then 1–2 weeks off

For injections, the recurring pattern is 250–500 mcg once a day, often starting at 250–300 mcg, for 2–4 weeks, followed by a break of 2–4 weeks. [25], [21], [27], [28]

Read these cautions before the numbers. Human studies gave Selank only as nose drops, in short courses, mostly to Russian adults with anxiety disorders. The spray and injection schedules come from protocol websites, not trials. [1], [16]

Do not stop or cut back prescribed medicine to try Selank. That includes antidepressants, benzodiazepines, sleeping pills, stimulants and mood stabilisers. Selank was studied added to, or compared with, anxiety medicines, never tested as a replacement for them, and stopping some of them suddenly can cause serious withdrawal effects. One public account describes sudden panic episodes after coming off an antidepressant and relying on Selank instead. In community education groups, some people describe making these changes without their prescriber. [18], [29], [30]
The label rules it out under 18, in pregnancy and breastfeeding, and with an allergy to its ingredients. [1]
Home-made sprays and research-powder injections are unverified. Their strength, purity and sterility are unknown, and there are no human safety data for injected Selank. [8], [31]
N-acetyl Selank amidate is a different molecule. It is sold under similar names, has no published human data, and its doses do not translate. [32]
Read the units. mcg means micrograms; 1 mg equals 1,000 mcg. The licensed 0.15% drops hold 1,500 mcg per mL, about 75 mcg per drop; a home-made spray holds whatever its mix and pump deliver. "Per nostril" amounts are half of the dose. On an insulin syringe, a unit measures liquid, not Selank; check any amount with the reconstitution calculator.

Titration Changing the amount in steps: The current label gives one fixed dose; the original allowed a single dose to be raised by repeating the drops after 15 minutes. [1], [15] Injection pages often start at 300 mcg for two weeks and move to 500 mcg. [28] One nasal-spray page starts at 250 mcg once a day for 2–3 days. [33] One page presents the move from 900 to 2,700 mcg a day as a titration, which neither the label nor the trials describe. [34]
Breaks and cycles: The label gives a 14-day course, repeated after 1–3 weeks when needed. Websites describe 4 weeks on and 4 off, 2–4 weeks on with an equal break, or 8 weeks on and 8 off, usually "to prevent tolerance". No study has tested whether breaks do that. [1], [28], [25], [35]

Low, mid and high are alternatives, not steps to move through. The cited references give the full details.

Where protocols differ: drops, sprays, injections and breaks ↓

Where these numbers come from

Label table. The first row reproduces the current Russian instruction for Selank 0.15% nasal drops (last changed July 15, 2025), checked against the manufacturer's 2017 instruction and the Vidal drug reference. The second row is the original instruction from the 2009 registration, still reproduced online, which gives single doses of 300–900 mcg and 900–2,700 mcg a day. The current label does not state a drop size; the microgram figures use the original instruction's 1 drop = 0.05 mL = 75 mcg, which the developer booklet and a Parkinson's study also use. The trial row comes from the full texts of the medazepam and phenazepam trials. [1], [36], [37], [15], [38], [39], [16], [17]

Spray and injection tables. Each row is one publisher's complete schedule: nasal low from a US compounding pharmacy's clinical guide, mid from DosingCalc and high from Peptide Dosing Protocols [19], [20], [21]; injection low from PeptaBase, mid from PeptideDeck and high from PeptideFox [24], [25], [26]. We compared 40 captured dosing pages (38 protocol rows) and re-checked the principal dose figures against the captured pages on September 24, 2026. The "most common pattern" sentences summarize the largest group of pages that state the same range; no median is calculated because most pages give ranges, not single amounts. Across 16 injection pages, the lower end of the stated range was most often 250 mcg and the upper end 500 mcg.

We keep amounts, frequency and course length together, rather than taking a low number from one page and a duration from another. Pages with clear arithmetic errors, N-acetyl Selank amidate rows, blends with unstated component amounts and animal doses do not define the typical comparison. No page cites a human study for injected Selank, and we found no treatment study. [40], [32], [41]

Row-specific notes: the nasal low row's stated maximum (600–800 mcg a day) is shown beside the maintenance range; the nasal high row repeats the trial's top daily amount without the trial's drop product; the injection low row is a "daily" schedule from a page that also gives 200–500 mcg 3–5 times a week. [19], [21], [24]

Open the searchable source directory

What is Selank commonly used for?

Most people look into Selank for anxiety: everyday worry, stress, social or performance anxiety, and anxiety that keeps them awake. Others want calmer focus, often alongside Semax, or hope it will help them come off a prescribed anxiety medicine. [42], [43], [44]

The Russian label lists anxiety and panic attacks, nervous exhaustion (neurasthenia), mood swings, sleep problems, low willpower, insecurity with other people and difficulty adjusting to stress, all in adults. The human studies tested some of these; the others rely on the label, personal accounts and animal research. The sections below keep them apart. [1]

Paired bar chart of six Russian Selank studies showing the number of people given Selank and the number in the comparison group, from 42 versus 20 in the 2008 medazepam comparison to 32 versus 32 in the 2024 post-COVID study, with how each group was assigned. It shows study sizes, not results. — Where the human evidence is. Each bar shows the people given Selank and the comparison group in a selected study, what they were compared with, and whether the groups were assigned at random. None compared Selank with a placebo, and most come from the developers' own research network. Sources: Medazepam comparison, 2008 · Phenazepam comparison, 2014 · Phenazepam add-on study, 2015 · Post-COVID study, 2024 · Antidepressant add-on and asthma reports, 2019 (manufacturer's publications page).

Anxiety and stress

This is where the human research is. Three Russian trials in adults with anxiety disorders gave 2,700 mcg a day as nose drops for 14 days and compared Selank with a tranquilizer: similar anxiety relief to medazepam, less relief than phenazepam after two weeks, and more responders than phenazepam a week after both were stopped. None used a placebo, and none describes hiding which treatment people received. The human research section gives the details. [16], [17], [18]

Russia's 2024 national guideline for generalized anxiety disorder does not mention Selank. [45]

Conceptual watercolor side view of the brain with three regions highlighted: the amygdala deep in the temporal lobe, the hippocampus beside it and the prefrontal cortex at the front. It shows anatomy only, not an effect of Selank. — Fear and worry involve a small almond-shaped area deep in the brain (the amygdala), the memory centre beside it (the hippocampus) and the front of the brain, which helps keep them in check. Rat studies of Selank measured changes in these areas; a brain-scan study in healthy people found a change in how the amygdala connects with nearby areas. This illustration explains anatomy; it is not clinical evidence.

Situational and performance anxiety

Many people use Selank only before a stressful event, such as a presentation, a flight or a dental visit, rather than every day. One described giving a talk to 150 people after 200–250 mcg by injection 2–3 hours earlier; others in the same thread felt nothing. [42], [46] In the first trial, 17 of 42 patients improved suddenly within the first days and the rest gradually, which is the closest the studies come to this use; no study has tested single doses before a stressful event. [16]

Sleep

The label lists sleep problems among the anxiety symptoms Selank is meant for, but no study has tested it as a sleep treatment. In the medazepam trial, night-time sleep problems were among the anxiety symptoms that eased, and in the phenazepam trial 13% of the Selank group reported sleeping longer by day 14. [16], [17] People use it at bedtime when racing thoughts keep them awake, and reports split: some fall asleep more easily, while others describe lying awake, nightmares or daytime sleepiness. [1], [47], [48], [49], [50], [51] In community education groups, sleep is one of the most common reasons for bedtime injections, and reports of vivid dreams and next-morning grogginess cluster at the higher bedtime doses.

Focus, memory and "brain fog"

This is another common reason, usually with Semax, and the least studied. An open pilot in 15 people aged 54–76 with anxiety reported better attention, short-term memory and reaction times after two weeks, and the trials recorded less tiredness (asthenia) as anxiety eased. No study has tested focus or memory in healthy adults. [52], [16]

Coming off benzodiazepines or antidepressants

This is the riskiest use. In one open trial, people who continued Selank for a week after stopping phenazepam were reported to have milder withdrawal, and a manufacturer-hosted report added Selank to an antidepressant; rat and mouse studies tested alcohol, morphine and tranquilizer withdrawal. None of this tested Selank as a replacement. [18], [53], [54], [55] In public forums and community education groups, people describe tapering antidepressants, benzodiazepines, sleeping pills or stimulants on their own with Selank, sometimes followed by panic attacks. Any change to a prescribed medicine belongs with the prescriber. [30], [56]

Immune and antiviral claims

Because it comes from tuftsin, Selank is sometimes sold as an immune booster. The evidence is animal and laboratory work: gene changes in mouse spleen, calmer inflammatory signals in stressed rats and less flu virus in cells and mice given it beforehand. One study in patients with anxiety measured blood immune signals, without a comparison group. [57], [58], [59], [60]

Other uses you may come across

Small Russian reports added Selank to treatment for asthma, eczema, menopause symptoms, tension headache, back pain, binge eating, Parkinson's-related anxiety and tiredness after COVID-19 (see human research). [61], [62], [63] ADHD-related restlessness and post-traumatic stress come up in public accounts but have not been studied. [64], [65] In community education groups, some people also add it for jittery or flat feelings on weight-loss injections.

Some community education groups list Selank for adrenal insufficiency (Addison's disease), while others say no peptide treats it. Selank has never been studied in adrenal disease.

Where do Selank protocols differ?

Selank amounts look simple until you notice that people count in drops, sprays, micrograms per nostril and syringe units, for three different kinds of product. Here is what changes between them and why it matters.

Is the number for one drop, one spray, one dose or the whole day?

A drop of the licensed drops holds about 75 mcg; a spray holds whatever its mix and pump deliver. The current label no longer gives the drop size, so every microgram conversion rests on the original 2009 instruction (4 drops = 0.2 mL = 300 mcg). Studies were not consistent either: one counted 4 drops as 150 mcg. [1], [15], [66]

Websites add their own errors: one calls the label dose 450 mcg a day (it is about 900), another says each drop holds 150–300 mcg, and a spray recipe labelled "0.15%" is ten times weaker than the licensed drops. [40], [67], [68] Several pages say the trials used about 900 mcg a day; they used 2,700 mcg. [25], [69], [20]

For home-made sprays, the strength depends on the mix: 10 mg in 2 mL gives about 500 mcg per 0.1 mL pump, and a mix of 2–3 mg per mL gives 200–300 mcg, if the pump really delivers 0.1 mL. [20], [70] In community education groups, a common mix is 10 mg in 10 mL, about 100 mcg a spray.

Range chart of Selank daily amounts: about 900 mcg on the current nasal-drop label, 900 to 2,700 mcg on the original label, 2,700 mcg in the anxiety trials, 900 to 1,800 mcg in other human reports, 250 to 1,500 mcg on nasal spray websites and 250 to 500 mcg on injection websites, which is untested in people. — Daily amounts compared. The licensed drops give about 900 mcg a day on the current label, and the anxiety trials used 2,700 mcg; website amounts mostly overlap the label amount and sit below the trial amount, and injections have never been studied. The bars compare amounts, not effects, and the routes differ. Sources: Selank label, 2025 (RLS) · Original instruction (Medvestnik) · Medazepam comparison, 2008 · Injection page example (PeptideDeck).

The studied route at lower doses

Pages that recommend nose drops because they are "the studied route" often give 250–500 mcg a dose or 300–900 mcg a day, well below the 2,700 mcg a day the trials used. [22], [69] Community education groups show the same split: educators describe nasal use as the evidence-based route, then suggest 600–1,000 mcg a day, and many members use one or two sprays a day. A lower amount by the studied route is still not a studied dose.

Nose drops, nasal spray or injection?

The human studies gave Selank as nose drops. Injections are common online, and people split on which route they prefer, but apart from one single-dose brain-scan study there are no human data on injected Selank: no safety study, no blood levels, no dose comparison. In mice, the two routes both eased anxiety but changed different brain receptors, so they may not be interchangeable. [71], [25] In community education groups, some people found that one route did nothing while the other worked, in both directions.

Every day, or only when needed?

The label and the trials used a fixed daily course. Online, people also take it only before stressful days, three or four times a week, or on weekdays for months. [1], [46], [72] None of these patterns has been compared.

Morning or bedtime?

The label spreads doses across the day, three times daily. Websites disagree: one advises morning doses for focus and evening doses for anxiety, another advises avoiding it within two hours of sleep because some people find it stimulating. [1], [24], [73] Reports of lying awake after a bedtime dose support the second caution for some people, while others use it to fall asleep. [48], [47]

How long, and are breaks needed?

The label course is 14 days, repeated after a 1–3-week gap if needed; the longest study course lasted 30 days. [1], [63] Websites instead describe 4–8-week courses, cycles such as 4 weeks on and 4 off, or 1 month on and 1 month off, usually to "prevent tolerance". [28], [24], [19] No study has tested tolerance or break lengths. In public forums and community education groups, some people use it daily or on weekdays for months to a year, far longer than any study.

How do micrograms convert to syringe units?

Selank for injection is sold as a freeze-dried powder in a vial that is mixed with sterile water (reconstitution). On a U-100 insulin syringe, units measure volume, not drug. For example, a 5 mg vial (5,000 mcg) mixed with 2 mL gives 2,500 mcg per mL, or 25 mcg per unit, so 250 mcg is 10 units and 500 mcg is 20 units. The same 250 mcg is 5 units if the vial is mixed with 1 mL. Doserly's reconstitution calculator works this out for any vial and shows each step. [25]

What happens when you stop Selank?

In the trials, stopping after 14 days caused no withdrawal symptoms, and in the phenazepam comparison the Selank group had more responders a week after stopping than at the end of treatment, while phenazepam's effect faded. The anxiety trials followed people for at most a week after stopping. Two smaller add-on reports, in binge eating and eczema, checked again about two weeks later and said the improvement had held. How often anxiety returns over months is unknown. [74], [75], [16], [17]

The label says Selank does not cause dependence or habituation, and allows a repeat course after 1–3 weeks. It gives no tapering advice. [1]
Coming off other medicines. In an open add-on study, people who kept taking Selank for a week after phenazepam was stopped were reported to have milder withdrawal; that is not a test of Selank as a substitute. [18]
Personal accounts range from no change on stopping, or a slow return to baseline over weeks, to anxiety returning within a course break or within an hour of a late dose. [72], [76], [77], [78] In community education groups, some long-term users say they cannot take breaks because their anxiety comes back. A return of the original anxiety is different from withdrawal, but neither has been studied.
Unwanted effects. One person's panic attacks slowly settled after stopping a compounded spray, and in community education groups, anxiety and poor sleep that began with Selank settled within about a week of stopping. [79]

Source-by-source comparison of Selank dosing pages

How do the dosing pages compare?

Unit key: 1 milligram (mg) = 1,000 micrograms (mcg). One drop of 0.15% Selank ≈ 75 mcg (original instruction); 0.15% = 1.5 mg per mL.

Six pages reproduce the current label, about 900 mcg a day in three doses for 14 days: Peptide Initiative (two pages), All About Peptides, PeptiTools, Peptide Dosages and PeptidesExplorer, which miscalculates it as 450 mcg. [80], [34], [81], [69], [82], [40] Others repeat the older 900–2,700 mcg range or stretch it to "250 mcg to 3 mg a day". [83], [67]

Injection pages fall into a few families. The largest gives 250–500 mcg once to three times a day for 2–4 weeks: PeptideFox, PeptideDeck, Peptide Dosing Protocols and PepGuru. [26], [25], [21], [27] A shared table steps from 300 mcg in weeks 1–2 to 500 mcg in weeks 3–4 (PeptideDosage.org and Peptides.ID). [28], [84] A lower family gives 100–300 mcg a day and 750–1,000 mcg by nose, credited to one physician's protocol book (Guide to Peptide, PeptaBase). [85], [24] One page stands alone at 1 mg two or three times a week, 8 weeks on and 8 off. [35]

Which pages contain errors?

PeptidesExplorer computes the label as 450 mcg a day (it is about 900). Pure Tested Peptides says a drop holds 150–300 mcg (about 75). Know Your Peptide's "0.15%" spray recipe is ten times weaker than the licensed drops. ParaHealth turns 2–3 drops per nostril three times a day into 1.5–2.25 mg (it is 0.9–1.35 mg). PeptideDeck, PeptiTools and DosingCalc say the trials used about 900 mcg a day (they used 2,700 mcg). [40], [67], [68], [33], [25], [69], [20]

Pages also misreport the studies: one gives the medazepam trial's groups as 30 and 32 (they were 42 and 20), one calls the post-COVID study randomized at 1.5 mg a day (neither is stated), one cites an unrelated bacteriology paper for "Russian randomized trials", and several call the licensed drops a spray. [34], [26], [24], [70], [86] Half-lives from 2–3 minutes to hours appear without a human measurement. [34], [28], [32]

Where do the website cycles come from?

The label gives a 14-day course and a 1–3-week gap before any repeat. Websites add 4 weeks on and 4 off, 2–4 weeks on with an equal break, 14 days on and 14 off, 1 month on and 1 month off, or 8 weeks on and 8 off, usually to prevent "tachyphylaxis" (tolerance). No tolerance study exists. [1], [28], [25], [87], [24], [35]

What are the registered studies planning?

Checked September 24, 2026: ClinicalTrials.gov and the World Health Organization's trial registry returned no Selank studies. The Russian clinical-trial permit register lists two 2004 permits for Selank with the protocol, phase and patient numbers left blank. [88], [89], [90]

Do nose drops, sprays and injections behave the same way?

Nobody knows, because Selank has never been measured in human blood in a published study, by any route. There is no human pharmacokinetics study, so there is no measured bioavailability, peak level or half-life for drops, sprays or injections. [8], [88]

The Russian label states that 92.8% of a nasal dose is absorbed, that Selank appears in the blood 30 seconds after dosing and that blood levels fall over 5–5.5 minutes. None of these figures cites a study, and we could not find one; they are label statements, not published measurements. [1], [37]

In rats, the intact peptide could be found in the blood for only 7–10 minutes, and its main active breakdown product was tuftsin. Radioactively labelled Selank reached brain tissue best when given through the nose, compared with injection into the abdomen, into a vein or by stomach tube. [91], [92], [93] In mice, nasal drops and injections into the abdomen both eased anxiety but changed different brain receptors. [71]

Is a home-made spray the same as the licensed drops?

Not necessarily. The licensed product is a 0.15% solution in water with a preservative (methylparaben), sold in a 3 mL dropper bottle; no spray form is registered. The label advises clearing a blocked nose first, because mucus can reduce absorption. [1], [36], [37]

A home-made or ready-made research spray has an unverified amount of peptide, an unknown pump volume and no stability data. Public accounts include a ready-made spray that "tastes like saline", a one-sided nasal reaction with a swollen lymph node and chills, and a sinus infection that one person blamed on an unfiltered home mix. [94], [95]

How long does Selank last in the body?

In people, its half-life is unknown. The label's "5–5.5 minutes" is unsourced, and in rats the intact peptide was gone from the blood within 7–10 minutes. [1], [91]

Website half-lives range from 2–3 minutes to 15–20 minutes, and one page claims half of an N-acetyl dose remains after 7 hours; none cites a human measurement. [34], [28], [32] How long an effect lasts is a different question from how long the peptide stays in the blood: in the phenazepam trial, the Selank group was still improving a week after the last dose. [17]

Is N-acetyl Selank amidate (NA-Selank) a stronger Selank?

It is a different molecule, with chemical caps on both ends, and we found no published study of it in people or animals. Pages give it doses of 200–600 mcg a day on the untested assumption that it lasts longer. [32], [26] Two public accounts describe strong, unpleasant mind-altering effects after N-acetyl Selank sprays, both with other substances in the background. [96], [97] In community education groups, educators disagree about whether the modified forms are stronger, and members are unsure whether differently labelled products contain the same molecule.

Is Selank acetate different from Selank?

It is the same peptide as an acetate salt, the form used in the licensed drops and in research papers. The FDA's compounding list names it as "Selank acetate (TP-7)". [36], [8]

Is there a Selank pill?

No. A developer review suggested that peptides of this family may survive digestion well enough to be taken by mouth, but no oral product exists and no study has tested oral Selank in people. [98]

How should Selank be stored, and how long does it last?

For the licensed drops, the answer comes from the label. For research powders and home-made sprays, no shelf life for human use has been established.

Licensed drops (current 2025 label). Keep at 2–8 °C, away from light, and do not freeze; unopened shelf life is 2 years. Once opened, keep at up to 25 °C for no more than 15 days. Older versions said "not above 10 °C". [1], [36], [15]
How long a bottle lasts. At the label dose of 12 drops a day (about 0.6 mL), a 3 mL bottle lasts about 5 days, so a 14-day course needs about three bottles; Russian reviewers report bottles lasting 3–8 days. [1], [15], [99], [100]
Research powder. Websites say to keep the dry powder frozen at −20 °C for long storage; others say the fridge or even room temperature, and one gives 24 months frozen, 12 in the fridge and 6 at room temperature. None cites a stability test. [21], [25], [20], [33]
Mixed vials and home-made sprays. Websites give anything from 14–21 days to about 30 days in the fridge without citing a Selank stability test. No study has measured how long a home mix keeps its strength, and the label's 15-day limit applies to drops that contain a preservative. [73], [23], [25], [22]

This guide does not cover mixing or injection technique; the Academy note below covers practical handling.

What do we actually know about Selank in people?

Less than its Russian approval suggests. The human studies are Russian, mostly from the network that developed Selank, and small. None of the studies in patients compared Selank with a placebo, the main trials were open-label or do not describe blinding, and none appears on ClinicalTrials.gov or the World Health Organization's trial registry; the only registration trace is two Russian trial permits from 2004 with the protocol details left blank. All the treatment studies gave Selank as nose drops. [88], [89], [90]

Conceptual comparison of cells in a laboratory dish, an animal study notebook, and human study records. Each answers a different research question. A lab finding cannot by itself establish patient benefit. — Cell studies explore biological activity. Animal studies explore effects in another species. Human studies must test outcomes in people with an appropriate design. These are different kinds of evidence, not interchangeable steps to a proven treatment.

What did the anxiety trials find?

Study	What researchers reported	What it cannot establish
Medazepam comparison, 2008	62 adults with generalized anxiety disorder or nervous exhaustion: 42 took Selank (2,700 mcg a day) and 20 took the tranquilizer medazepam for 14 days. Anxiety scores fell by similar amounts; Selank also eased tiredness. 17 of 42 improved suddenly and 25 gradually. Side effects were rare and brief: possibly caused by Selank in 3 of 42 patients, against side effects in 65% of the 20 on medazepam; no withdrawal after stopping.	How patients were assigned and whether anyone was blinded are not described. The PubMed summary lists the groups as 30 and 32, which is the split by diagnosis, not by treatment. [16]
Phenazepam comparison, 2014	60 adults with phobic or bodily anxiety, randomly assigned: 30 took Selank (2,700 mcg a day) and 30 took phenazepam (2 mg a day) for 14 days. At day 14, anxiety scores fell 26.3% with Selank and 55% with phenazepam (5 versus 7 responders). A week after both stopped, 17 on Selank were responders versus 9.	Open-label (everyone knew their treatment), two Moscow hospitals, one week of follow-up. [17]
Add-on study, 2015	70 adults: phenazepam plus Selank (40) versus phenazepam alone (30) for 14 days; 40% versus 23% responded, a difference that could be chance. Of 20 who then continued Selank alone for a week, 75% were responders at day 21, against 30% of those whose phenazepam was simply stopped.	Open-label; the continuation group was small and was not a separate randomized comparison. [18]
Fast and slow responders, 2012	20 people with generalized anxiety disorder: 8 improved within 3 days and 12 by day 14.	Conference abstract only; no comparison group. [101]
Older adults, 2010	15 people aged 54–76 who had not improved on a week of dummy drops: less anxiety and fatigue and better attention and memory tests after 14 days.	No comparison group. [52]

In the phenazepam trials, "responders" were people whose anxiety score fell by at least half by day 14. The anxiety scores were the Hamilton anxiety scale and similar questionnaires, which measure symptoms, not how well someone functions day to day.

Bar chart from one trial of 60 adults: at day 14, 5 of 30 on Selank and 7 of 30 on phenazepam were responders; at day 21, a week after both were stopped, 17 on Selank and 9 on phenazepam were responders. — The 2014 phenazepam comparison, during treatment and a week after stopping. Phenazepam had more responders at day 14; a week after both were stopped, Selank had more. This is one open-label trial of 60 people. Sources: Medvedev et al., 2014 (PubMed).

Is Selank as strong as a benzodiazepine?

It depends on the trial. Against the benzodiazepine medazepam, anxiety relief was similar with fewer side effects. Against phenazepam, another benzodiazepine, Selank worked more slowly and less during treatment but held up better after stopping. [16], [17] Both trials were small and neither reports blinding, so neither settles the question. Doctors and users reviewing it online often call it mild, and in community education groups, some people with long-standing panic keep a prescribed medicine for attacks. [102], [103]

What other human reports exist?

These are smaller and weaker, and most are hosted on the manufacturer's website. Several share authors and possibly patients, and none used a placebo. [38]

Added to an antidepressant, 2019. 35 people on escitalopram plus 1,800 mcg a day of Selank for 14 days versus 20 on escitalopram alone: anxiety symptoms fully resolved in 89% versus 15%. [53]
Tiredness after COVID-19, 2024. 32 patients given drops 4 times a day for 30 days with other treatment, compared with 32 on the other treatment alone: better recovery of mental performance and less anxiety and low mood. How patients were assigned is not stated. [63]
Eczema (atopic dermatitis), 2020. 65 patients randomly assigned to standard treatment with or without Selank for 14 days: by day 30, anxiety scores fell 2.4-fold with Selank versus 1.3–1.4-fold without. [75], [62]
Asthma, 2019. 40 patients given Selank with asthma treatment versus 30 on asthma treatment alone: less anxiety. [61]
Stress and adjustment, binge eating, headache, menopause, back pain and Parkinson's disease. Groups of about 15–32 people given 900–1,350 mcg a day for 14–21 days, reporting symptom improvements; some had an untreated comparison group and some had none. [104], [74], [66], [105], [106], [39]

Has Selank been tested in healthy people?

Only briefly. A brain-scan study of 52 healthy volunteers compared one dose of Selank, Semax or placebo (its summary says the dose was injected) and found a change in how the amygdala, a fear-processing area, connects with nearby areas 5–20 minutes later. It did not measure anxiety, focus or safety. [107] No study has tested whether Selank improves focus, memory or stress in healthy adults over days or weeks.

How might Selank work?

Nobody knows how Selank works in people. The explanations below come from rat and mouse studies and from cells and blood samples in a dish, almost all from the developers' network. Rodent doses (typically 100–3,000 mcg per kilogram) cannot be converted into human doses. [108], [109]

Conceptual glassy illustration of a junction between two nerve cells: GABA molecules crossing to ring-shaped GABA receptors, and nearby enzymes cutting short enkephalin peptides. It represents laboratory and animal findings, not a measured effect of Selank in a person. — Two proposed explanations from laboratory and animal work: Selank may make GABA receptors, the brain's main calming switches, respond more strongly, and it may slow the enzymes that break down enkephalins, the body's own calming, opioid-like peptides. Neither has been measured in a living human brain. This illustration explains a concept; it is not microscopy or clinical evidence.

Does Selank act on GABA, the brain's calming system?

In laboratory tests, possibly. GABA is the brain's main calming messenger, and benzodiazepines work by strengthening its receptors. In binding tests, Selank made GABA stick to its receptor more strongly and interfered with diazepam's effect on the same receptor. [110] In rats, one nasal dose changed the activity of 29 of 77 nerve-signalling genes measured in the front of the brain within an hour; 25 of them also changed after a dose of GABA itself. [109]

The picture is not simple. In human nerve-like cells grown in a dish, Selank alone changed none of 84 genes tested, but it blunted GABA's effect and strengthened the antipsychotic olanzapine's. [111] In slices of rat brain, it increased the calming (inhibitory) signals nerve cells receive. [112], [113]

Does it slow the breakdown of enkephalins?

In blood samples, yes. Enkephalins are the body's own short, opioid-like peptides involved in pain and stress. In human blood serum in a dish, Selank blocked the enzymes that break them down, at laboratory concentrations. [114], [115] People with generalized anxiety broke enkephalins down faster than healthy people, and in the medazepam trial this breakdown slowed with Selank. [115], [16] In mice, the opioid blocker naloxone changed Selank's effects, which fits this idea without proving it. [116], [117]

Does it affect serotonin, dopamine or BDNF?

In rodents, it shifted serotonin, noradrenaline and dopamine chemistry in ways that differed between mouse strains. Rat studies also report changes in BDNF, a growth-support protein for nerve cells, in the hippocampus. None of this has been measured in people. [118], [119], [120], [121]

Is Selank an immune peptide?

It is built from one, and animal and cell studies suggest immune effects: changed inflammation genes in mouse spleen, calmer inflammatory signals in stressed rats, and less flu virus in cells and in mice dosed beforehand. In blood cells from patients with depression, it switched off the gene for the inflammatory signal IL-6 in a dish, although the amount of IL-6 in the same cultures rose. No study has shown fewer infections or any other immune benefit in people. [57], [58], [59], [60]

Does it affect blood clotting or blood pressure?

In rats and in laboratory tests, Selank thinned the blood slightly (an anticoagulant effect), increased clot-dissolving activity and reduced platelet clumping. [122], [123], [124] Given into a vein in anaesthetized cats, it lowered blood pressure by about a third for 1–3 minutes. [125] There are no human data on bleeding or blood pressure; the clotting findings are a theoretical reason for caution with blood thinners or before surgery.

Does Selank lower cortisol?

We found no human study that measured cortisol or other stress hormones with Selank, so claims that it "lowers cortisol" have no human evidence behind them. Some courses in community education groups make this claim without a source.

What are the risks and unanswered questions?

Is Selank safe?

Nobody has shown that it is safe beyond short courses of the licensed drops. In trials lasting 14–30 days, Selank caused few and mild problems, mainly a dry nose and occasional memory or concentration complaints, but most studies were small and did not describe in detail how they checked for side effects. There are no long-term, pregnancy or injection safety data, and the animal safety testing is known only from a developer summary and a patent statement, not published studies. The FDA says it lacks important information about the safety of Selank acetate in people. [16], [17], [38], [6], [8]

What side effects have been reported?

Problem	What was reported	Source
Nose and taste	The phenazepam trial's authors called a dry nose the most pronounced Selank effect, and their table also lists memory complaints (10%) and longer sleep (13%) at day 14; the label lists an unpleasant taste when drops run into the throat. One ready-made spray caused one-sided nasal irritation, a swollen lymph node and chills	Trial, label, public account [17], [1], [95]
Allergy	Allergic reactions, including delayed ones, with frequency unknown; the preservative methylparaben can cause allergy	Label [1]
Drowsiness	Sleepiness by lunchtime; eyes closing while driving; feeling "too chill" at 1 mg	Russian reviews, public account [99], [126], [127]
Irritability or more anxiety	Irritability in the first days; tension, anxiety and a sleepless night after a bedtime dose; anxiety rising to panic on day 5 in someone also taking other medicines	Public accounts [128], [129], [48], [130]
Blood pressure and flushing	A rise in blood pressure with shaking 20–30 minutes after a dose of the licensed drops (2 reviews); a burning, flushed face; a feeling of high blood pressure for 12–18 hours; mild hot flashes at 500 mcg by injection	Russian reviews, public accounts [131], [132], [51], [42], [64]
Mood and dreams	Tearfulness, low mood, nightmares and a nervous tic; brain fog and loss of pleasure after 1–2 weeks of benefit	Russian review, public account [50], [133]
Other single reports	Ringing in the ears, headache, increased hunger	Public accounts [134], [76], [135], [136]

Personal accounts cannot show cause, and many involve Semax or other substances. They show what has been noticed, not how often it happens.

Can Selank make anxiety worse?

In some people, it appears to. Public accounts describe more anxiety, tension or panic soon after starting, including one person who took the licensed drops and one whose anxiety returned when the injections were restarted. [48], [130], [137], [79] In community education groups, a small number of people describe the same, usually settling within about a week of stopping; educators there suggest first checking whether another anxiety medicine was recently stopped, because rebound from that can look like a Selank reaction.

Does Selank make you sleepy? Can you drive after taking it?

The trials found no benzodiazepine-like sedation, and attention and word tests did not worsen, although a few Selank patients reported memory or concentration complaints; the label says Selank does not affect driving. [17], [1] Some users disagree: one Russian reviewer described her eyes closing at the wheel, and in community education groups, drowsiness, yawning and next-morning grogginess come up at doses above about 500 mcg. [126]

Is Selank addictive? Does it cause tolerance?

This has not been properly studied. The label says Selank does not cause dependence, and the trials saw no withdrawal after 14 days, but no study was designed to test dependence or misuse, and a US pharmacology review calls Selank poorly studied and urges testing of GABA-acting drugs for misuse potential before they reach the public. [1], [16], [29]

Tolerance has never been tested in people. In rats, a daily 4-week course kept working, and a developer summary reports no tolerance in animals up to 30 days. [138], [38] Some users describe the effect fading after two weeks to a month of daily use; others describe steady effects. [139], [140], [43]

Does Selank cause hair loss?

No study has looked. Two people online describe hair loss, one during 8 months of mostly daily Selank and one after stopping a long course of Semax and Selank, while another long-term user reports none. None of these accounts can show cause, and the claim that it happens through BDNF is speculation. [141], [142], [103]

Could product quality change the risk?

Yes. The licensed drops are made under Russian drug rules; research powders and sprays are not. The FDA flags a risk of immune reactions from clumping (aggregation) and peptide impurities in compounded Selank, and Belgian control laboratories identified Selank among seized products of the kind sold online as powders and nasal sprays. [8], [31] Buyers online have reported a blue powder sold as Selank, a ready-made spray that tasted like salt water, and a seller that tests purity but not sterility. [143], [94], [95]

Is Selank legal? Is it FDA-approved?

Checked September 24, 2026. Rules differ by country and change quickly. A "research use only" label does not make a product legal to sell or safe to use.

United States. Selank is not an FDA-approved medicine. The key points:

Compounding. US pharmacies may compound with a bulk ingredient only if it has an official monograph, is part of an approved drug, or appears on the FDA's list of bulk substances allowed for compounding. Selank is on no approved list and in no approved drug. [144], [145]
Safety listing. The FDA's list of compounding ingredients that may pose significant safety risks names "Selank acetate (TP-7)" as nominated but withdrawn, warning of possible immune reactions and a lack of human safety information. [8]
In practice. US telehealth and compounding pages still advertise compounded Selank sprays, and some US clinics prescribe it. [70], [19], [146] A widely shared 2024 claim that the FDA "banned" Selank misread the safety listing. [147]
No other federal action. No Federal Register notice or federal regulation names Selank. [148], [149]

Canada. No Selank product is authorized. Health Canada named seized unauthorized injectable Selank in advisories about a Calgary clinic (April 1, 2025) and an online seller (August 1, 2025). [9], [150], [151]

Australia. Selank is not on the Australian Register of Therapeutic Goods and is not named in the June 2026 Poisons Standard. The medicines regulator warned in May 2026 that poorly labelled imported peptides are being seized. A missing name does not make it legal to sell or import. [10], [152], [153]

United Kingdom and Europe. There is no UK-licensed Selank product and no product authorized through the European Medicines Agency; national approvals in individual EU countries were not checked. [11], [12]

Russia and Ukraine. In Russia, the 0.15% drops are a registered medicine sold without a prescription since 2017. A Ukrainian registration, where it was prescription-only, expired on August 30, 2016, so pages calling it approved in Ukraine are out of date. [5], [2], [154], [155]

Is Selank banned in sport? Does it show up on a drug test?

It is not named on the World Anti-Doping Agency's 2026 or 2027 lists. Their S0 rule bans substances with no current approval by any government health authority; because Selank is approved in Russia, it is unclear whether S0 covers it, and Polish anti-doping scientists list its status as unclear. [156], [157], [158] The US drug-reference service used by athletes has no entry for it, and the US anti-doping agency advises athletes to avoid anything sold as a research chemical. [159], [160] We found no published test for Selank in urine or blood, although laboratories can identify it in products. [31]

Who should be especially cautious?

The label rules out the first three groups. The others are cautions from studies or have simply not been studied, which is a reason for caution, not proof of harm.

Children and teenagers. Ruled out under 18; no study has included them. [1] One public account describes heavy nasal use of Selank with two other peptides between the ages of 12 and 14, with emotional numbness at the time, and in community education groups some parents describe giving it to teenagers. [161]
Pregnancy and breastfeeding. Ruled out; not studied. [1]
Allergy to the ingredients, including the preservative methylparaben. [1]
Anyone taking antidepressants, benzodiazepines, sleeping pills, stimulants or mood stabilisers. Interactions are largely untested, and changes to these medicines belong with the prescriber. [1], [18], [53]
Bipolar disorder, psychosis, post-traumatic stress or a history of seizures. Not studied. In community education groups, people with these conditions use Selank without any data to guide them.
Blood thinners or upcoming surgery, because of the animal clotting findings. [122], [124]
Drug-tested athletes, because of the S0 rule. [156]

Can Selank be taken with antidepressants, benzodiazepines or alcohol?

Not in a formal interaction study. The label says no interaction has been found with the antipsychotic haloperidol, two barbiturate sedatives, stimulant-type drugs or alcohol, without describing how this was tested. [1] In people, Selank has been given alongside phenazepam in an open trial and alongside escitalopram in a manufacturer-hosted report. [18], [53] In mice it strengthened diazepam's anti-anxiety effect and reduced its sedation, and in human cells it strengthened olanzapine's effect on genes. [162], [111] One person described a racing heart after a cannabis (delta-8) gummy while taking Selank. [163]

Nothing is known about Selank with Semax, its usual partner, over the long term, or with ADHD medicines. Bring a complete list of everything you take to a pharmacist or doctor.

What should be monitored while using Selank?

The Russian label sets no blood tests or check-ups. What exists is a record of what the studies measured, which can help you prepare questions for a clinician; it is not a personal testing plan.

What does the label ask for?

No routine tests. The label lists who should not use Selank and warns about allergic reactions to the drops or their preservative; the label also advises clearing a blocked nose before dosing. [1], [36], [37]

What did the human studies check?

Symptoms. Anxiety and mood questionnaires (such as the Hamilton anxiety scale and a patient self-rating scale), a doctor's overall rating, a side-effect checklist and quality-of-life scores. [16], [17]
Thinking. Attention and word-finding tests, which showed no impairment with Selank. [17]
Body checks. The medazepam trial took blood counts, a urine test and a heart tracing (ECG) at the start and end, without reporting the results. [16]
Research measures. Enkephalin breakdown in blood, blood immune signals, brain waves (EEG) and brain scans. [16], [60], [52], [107]

Which signals matter, and why?

A severe allergic reaction needs urgent medical care rather than tracking [1], and so do thoughts of self-harm or a panic attack that does not settle.

Why it matters	What studies, labels or reports flagged	Tracking category
Anxiety	Relief builds over days to two weeks in trials; some people get more anxious, or find anxiety returns on breaks [16], [78]	Anxiety; Stress Tolerance
Sleep	Used for sleep but can keep some people awake, with nightmares in some reports [48], [50]	Sleep Quality
Daytime drowsiness	Reported despite the label's driving statement [126]	Energy Levels; Side Effect Burden
Mood and irritability	Irritability in the first days; tearfulness or flat mood in some accounts [128], [50], [133]	Mood & Wellbeing; Emotional Regulation; Emotional Aliveness
Blood pressure and flushing	A few reports after doses of the licensed drops [131], [51]	Blood Pressure; Temperature Regulation
Changes to other medicines	Any change to a prescribed medicine, made with the prescriber, can cause its own symptoms that are easy to blame on Selank; educators in community education groups raise this	Withdrawal Symptoms
Nose	Dryness in trials; irritation with sprays [17], [95]	Side Effect Burden

These come from small studies and personal accounts, so they show what has been flagged, not what a person will experience.

What do people in public communities report?

Russian review sites, English-language forums and community education groups contain grateful reports, flat disappointments and a steady trickle of drowsiness, irritability and sleep complaints, often in the same thread. Russian reviewers mostly used the licensed drops, often on a doctor's or pharmacist's suggestion; English-speaking users mostly use research sprays or injections, and most take other things too. These are selected discussions, not a survey of everyone who has tried Selank.

On the largest Russian review site, 39 reviews of the licensed drops average 3.6 out of 5, with 61% recommending them. The site warns that commissioned advertising reviews were found on the page, and one reviewer says a manufacturer representative asked her to remove a negative review. [164], [50]

What do the positive reports look like?

The typical success story is a quieter mind rather than a lift: less rumination and reactivity, calm without feeling sedated. One person on a daily 250 mcg injection, whose antidepressant had stopped working, said they no longer felt panicky by the third week; another described steadier mood on 200 mcg sprays five or six days a week. [146], [72] Russian reviewers describe calmer responses to stress and better sleep during a course. [165], [164] In community education groups, several people say they noticed the effect mainly when they stopped.

How fast does it work, and how long does it last?

Reports range from minutes to a week. Russian reviewers of the licensed drops describe feeling calmer within about 10 minutes, one after placing the drops on the nasal septum with the nostril pinched, while others noticed a change only on the second to fifth day. [166], [167], [164], [168], [169] One injection user feels calmer within about 30 minutes, and a spray user noticed less anxiety after about a week. [103], [170] In community education groups, nasal doses are described as faster and shorter-lasting than injections, and a single morning injection as wearing off by mid-afternoon for some.

Does everyone notice something?

No, and "nothing happened" is one of the most common stories. One person used a full bottle of ready-made spray at a stated 600 mcg a day with no effect; another injected 500 mcg with Semax for a week and felt nothing; Russian reviewers call it as weak as valerian or say it did nothing at all, and doctors reviewing it online call the effect "very average". [171], [172], [173], [174], [102] The explanations offered (too little per spray, a poor batch, the wrong route) are untested. In community education groups, nonresponders appear on both routes, and some ready-made sprays turned out to hold only 25–50 mcg a spray.

What unwanted effects come up?

The recurring complaints are drowsiness, early irritability, lying awake after an evening dose and, less often, anxiety that rises instead of falling. Single reports include flushing, a rise in blood pressure, nightmares, ringing in the ears and hunger; the risks section lists them with sources. [51], [129], [48], [134] In community education groups, vivid dreams and next-morning grogginess cluster at bedtime injections of about 500 mcg to 1 mg, and feeling unmotivated or flat at the highest doses.

Does it stop working over time?

Some say it does. One person on the licensed drops felt it losing effect after a month of daily use and switched to one week on, one week off; another found it stopped working after about two weeks. [139], [140] One Russian reviewer felt well for two weeks after a first course, but a second course did not help and brought irritability. [77] Others describe steady effects over months. [43] No study has tested tolerance.

How can you judge a Selank story?

Ask: Was it the licensed drops, a home-made spray, an injection, or N-acetyl Selank amidate sold under a similar name? How many micrograms, rather than "sprays" or "units"? What else changed: Semax, a new or stopped antidepressant, sleep aids, alcohol, a stressful month ending? Was anything measured, or only felt? Did the person post again weeks later? Anxiety naturally rises and falls, so one calm week proves little.

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A learning path for Selank readers

Start with the basics What peptides are, how they are prepared, stored and measured, and the safety questions to ask first.
Go deeper on calm and focus peptides How anxiety and nootropic peptides differ, what the studies measured, and why the product you hold matters.
Plan and track with your care team Turn what you learn into questions, tracking and a plan you can review with a professional, especially around prescribed medicines.
Keep the tools close Checklists, tracking templates and quick-reference tables for peptides and bloodwork.

Plus community discussions where members share what they are tracking and what they are still unsure about.

How does Selank compare with Semax, DSIP and N-acetyl Selank amidate?

These are the peptides most often bought alongside Selank or confused with it. Of the four, Selank, Semax and DSIP are registered as nose drops in Russia; none is approved in the United States.

Peptide	What it is	How it is taken	Human evidence	Approval status
Selank (this guide)	Seven amino acids: tuftsin plus Pro-Gly-Pro [3]	0.15% nose drops, 2 drops in each nostril 3 times a day for 14 days (label) [1]	Small Russian anxiety trials against tranquilizers, with no placebo [16], [17]	Non-prescription medicine in Russia; not FDA-approved [2], [8]
Semax	Seven amino acids from a fragment of ACTH, a stress hormone; shares Selank's Pro-Gly-Pro end [175]	0.1% nose drops, 2–3 drops in each nostril 2–4 times a day for 3–14 days, depending on the use (label) [176]	Small Russian stroke and brain-circulation studies, mostly not randomized [175]	Prescription medicine in Russia; FDA advisers voted 8–5 (1 abstaining) in July 2026 to recommend allowing compounding, which is not an FDA decision [177]
DSIP	Nine amino acids, first found in 1977 in rabbits during induced sleep [178]	Sleep studies gave it into a vein; Russian nose drops hold 300 mcg per ampoule [179], [180]	Small 1980s sleep studies; controlled results weak [179], [181]	Nose drops registered in Russia; not FDA-approved; advisers voted 6 yes, 7 no, 1 abstaining on compounding [180], [182]
N-acetyl Selank amidate	Selank with chemical caps on both ends [32]	Research sprays and injections; no tested human dose [32]	None found	No approval found

The real differences are in what has been tested. Selank has small trials in anxiety, Semax in stroke and brain circulation, DSIP in sleep, and the N-acetyl form in nothing. The only direct comparison is the brain-scan study of 52 healthy people given Selank, Semax or placebo, which did not test symptoms or safety, so the table cannot say which works better or is safer. [107]

Selank and Semax come from the same Moscow institute and manufacturer and are often combined: Semax in the morning for focus and Selank later for calm, or both in one vial or spray. The FDA's Semax review found US websites selling combined products, including a 50:50 injectable. Stack pages usually give Selank 250–500 mcg alongside Semax. The combination has never been studied, and in a mixed product the amount of each per dose depends on how it was made. [175], [183], [184] In community education groups, a common suggestion is to start the two separately, so each effect can be told apart.

Common questions about Selank

How long does Selank take to work?

In the trials, some patients improved within the first days and the rest over two weeks. [16] Personal accounts range from minutes after a nasal dose, or about half an hour after an injection, to a week or more, and many people notice nothing. [167], [103], [171] The phenazepam trial found Selank still improving a week after the course ended. [17] See what people report.

Is Selank a benzodiazepine? Does it work like Xanax?

No. Selank is a peptide, not a benzodiazepine, although laboratory tests suggest it acts on the same calming receptor system (GABA). In trials it matched the benzodiazepine medazepam but worked more slowly and less strongly than phenazepam during treatment; it has never been compared with alprazolam (Xanax). [110], [16], [17] See how it might work.

Can Selank replace an antidepressant or a benzodiazepine?

There is no evidence that it can. Selank has been studied alongside or against these medicines for two weeks, never as a replacement; one open study kept people on Selank for a week after phenazepam was stopped, which is not a test of switching. Stopping some of these medicines suddenly can cause serious withdrawal effects. One public account describes panic attacks after coming off an antidepressant with Selank. Any change to a prescribed medicine belongs with the prescriber. [18], [29], [30] See who should be cautious.

Is Selank the same as Semax? What is the Semax and Selank stack?

No. Semax is a different seven-amino-acid peptide from the same Russian developers, built from a stress-hormone fragment and sold as prescription drops for stroke and memory problems; the two share only their last three amino acids. The "stack" usually means Semax in the morning and Selank later, or both in one spray or vial, and the combination has not been studied. [175], [176] See how they compare and the Semax guide.

Does Selank help with sleep?

No study has tested it as a sleep treatment; the trials tracked sleep only as one anxiety symptom. The label counts sleep problems among the anxiety symptoms it is meant for, and some people fall asleep more easily when racing thoughts are the problem, while others lie awake or have nightmares after an evening dose. [1], [47], [48] See morning or bedtime.

Is Selank legal to buy? Is it approved in Russia?

In Russia, the 0.15% drops are a registered medicine sold without a prescription. In the US, Selank is not FDA-approved and not on the list of ingredients pharmacies may compound, and we found no approval in Canada, Australia, the United Kingdom or the European Union. The Russian approval covers the licensed drops, not research powders, and a "research use only" label does not make a product legal to sell. [5], [8], [9] See the dated legal-status summary.

Can you take Selank every day, long term?

Long-term daily use has not been studied. The label course is 14 days, repeated after a 1–3-week gap when needed, and the longest study course was 30 days. Month-long cycles and year-long weekday use online are conventions, not tested plans. [1], [63], [24] See where protocols differ.

Glossary

Plain explanations of the route, dosing, brain and research terms used in this guide. Underlined terms in the text link here.

Adverse event: A harmful or unwanted medical event reported after someone used a treatment. A report alone does not prove the treatment caused it.
Aggregation: Peptide molecules clumping together. Clumps can make a product weaker and, when injected, more likely to trigger an immune reaction.
Amino acid: A small chemical building block. Chains of amino acids make up peptides and proteins.
Animal study: Research in animals such as rats or mice. It shows what a substance does in a living body, but results in people can differ.
BDNF: Brain-derived neurotrophic factor, a protein that helps nerve cells survive, grow and form connections.
Benzodiazepine: A class of prescription tranquilizers, such as diazepam, alprazolam and phenazepam, that strengthen the brain's GABA calming system. They can cause sedation and dependence, and stopping them suddenly can be dangerous.
Bioavailability: How much of a dose reaches the bloodstream in a usable form. It depends heavily on the route.
Cell study (in vitro): Research on cells or blood samples in a dish. It gives early clues about biology, but it is far from proof of benefit in people.
Compounding: When a pharmacy prepares a customized medicine from individual ingredients. In the US, federal rules control which bulk ingredients pharmacies may use.
Controlled trial: A study that compares people who receive a treatment with a similar group who do not, or who receive a different treatment or a placebo. Randomly assigning people to each group makes the comparison fairer.
Course and cycle: A course is the period of repeated use, such as 14 days. A cycle is a course plus a planned break before any further use.
Daily total: All the amounts given in one day, added together. For example, 300 mcg three times a day is a 900 mcg daily total.
Dose (amount each time): The amount given on one occasion. A protocol lists both the dose and how often it is given.
ECG: Electrocardiogram, a recording of the heart's electrical activity taken with pads on the skin.
EEG: Electroencephalogram, a recording of the brain's electrical activity (brain waves) taken with sensors on the scalp.
Enkephalins: Short peptides the body makes that act on opioid receptors and help dampen pain and stress. Enzymes in the blood and brain break them down within minutes.
GABA: Gamma-aminobutyric acid, the brain's main calming (inhibitory) messenger. Benzodiazepines work by strengthening its receptors.
Half-life: The time it takes for the measured level of a substance in the blood to fall by half. It is not the same as how long an effect lasts.
Intranasal: Given into the nose, as drops or a spray, to be absorbed through its lining. The licensed Selank drops are intranasal.
Investigational: Still being studied and not approved by a regulator, such as the FDA, to treat any condition.
Freeze-dried (lyophilized): Dried by freezing and removing the water, leaving a powder. Research Selank is sold this way and mixed with liquid before use.
mcg and mg: Micrograms and milligrams. 1 mg equals 1,000 mcg. A drop of the licensed 0.15% Selank holds about 75 mcg.
Neurasthenia: A diagnosis still used in Russia for long-lasting nervous exhaustion: tiredness, irritability, poor concentration and poor sleep, often with anxiety.
Open-label: A study in which patients and researchers know who receives which treatment. Expectations can then affect the results, especially for symptoms like anxiety.
Peptide: A short chain of amino acids. Selank is a chain of seven.
Pharmacokinetics: How the body absorbs, moves, breaks down and removes a substance.
Placebo: A dummy treatment with no active ingredient, used as a comparison in studies.
Preclinical research: Studies done before research in people: cell studies and animal studies.
Reconstitution: Mixing a freeze-dried powder with a liquid so it can be measured. The amount of peptide in the vial and the volume of liquid added together set how much each unit or spray holds.
Registered medicine: A medicine a country's regulator has approved for sale for specific uses, with an official label. Selank is registered in Russia, not in the United States or the European Union.
Research use only: A label on products sold for laboratory research. It does not mean a product is approved, tested for human use or legal to sell as a medicine.
Responder: In a trial, a person whose symptom score improved by at least a set amount. In the Selank phenazepam trials, the anxiety score had to fall by at least half.
Subcutaneous (SC): Injected into the fatty layer just under the skin. Many online Selank users inject this way, although no human study has tested it.
Syringe units: Markings on an insulin syringe that measure volume. On a U-100 syringe, 100 units equal 1 mL. The amount of drug per unit depends on the vial's concentration.
Titration: Adjusting a dose in steps, usually starting lower and increasing if needed.
Tuftsin: A natural four-amino-acid peptide (Thr-Lys-Pro-Arg) that acts on immune cells. Selank is tuftsin with three amino acids added, and the body breaks Selank back down to tuftsin.
WADA: The World Anti-Doping Agency, which publishes the list of substances banned in sport.
Withdrawal and rebound: Withdrawal effects are symptoms caused by stopping a substance. A rebound is a problem returning worse than before after stopping. Neither has been properly studied for Selank; follow-up after stopping lasted about two weeks at most.

Explore more of the research

Go deeper into the animal and laboratory experiments behind the mechanism claims.

Across this guide, the citations include 60 original scientific papers: 18 human studies and 42 cell and animal studies. The optional library below summarizes selected animal and cell papers by question. Paper counts are not counts of independent research teams: most Selank papers come from one Moscow research network.

In the route details, intraperitoneal means into the abdominal cavity and intravenous means into a vein.

Anxiety and behaviour in animals · 7 papers

Only anxious mice respond. In a high-anxiety mouse strain, Selank prevented anxious behaviour across 200–3,000 mcg/kg into the abdomen, without the slowing seen with benzodiazepines; a calm strain showed no effect. [108]
Enkephalins in mouse blood. At 100 mcg/kg, Selank eased anxiety and slowed the breakdown of an enkephalin in the blood of anxious mice only. [185]
Four weeks of daily dosing. In rats, a daily course reduced anxious and fearful behaviour from day 2, with the effect lasting through four weeks and no change in weight. [138]
Depression-like behaviour. Results depended on the dose: low single doses were active in mice, while repeated or higher doses were not; in a rat strain prone to depression, high repeated doses helped. [186]
Monkeys. In monkeys with experimentally induced "neurosis", nasal Selank reduced fear and aggression and improved memory for a long time. [187]
The opioid link. Naloxone, an opioid blocker, weakened Selank's anti-anxiety effect in one mouse strain and strengthened it in another. [116]
With diazepam under stress. Under chronic unpredictable stress in rats, Selank plus diazepam returned anxiety measures to their pre-stress levels. [188]

Learning, memory and withdrawal models · 8 papers

Slow learners. Selank improved learning in rats with low learning ability from the first dose, with the effect growing over four days. [189]
Memory that lasts. One injection during memory formation kept the learned response stable for 30 days in rats and briefly raised serotonin turnover. [190]
Damaged brain chemistry. Selank restored learning in rats with early damage to their dopamine and noradrenaline systems, and prevented memory loss caused by the drug actinomycin D. [191], [192]
Alcohol withdrawal. One dose removed withdrawal-related anxiety and pain sensitivity in rats without changing how much alcohol they drank. [54]
Alcohol sensitization. Like naloxone, Selank blocked the growing hyperactivity that repeated alcohol causes in mice. [193]
Morphine withdrawal. In rats, Selank reduced an overall morphine-withdrawal score by 39.6%, against 49.3% for diazepam. [55]
With tranquilizers. In anxious mice, adding Selank to diazepam or a similar drug increased the anti-anxiety effect and prevented the drop in movement the tranquilizers caused. [162]

Genes, immunity, gut, liver and safety tests · 7 papers

Brain genes. One nasal dose changed 36 genes in the rat hippocampus more than twofold, and a course changed 20, mostly genes for membrane proteins. [194]
Stomach. Selank and its breakdown products reduced the area of experimental stomach ulcers in rats. [195]
Liver under stress. In stressed rats, Selank lowered blood liver enzymes and changed the liver's antioxidant enzymes. [196]
Embryonic stem cells. In mouse embryonic stem cells, Selank barely changed growth or survival, but at the highest concentration 61% fewer GABA-making nerve cells formed. [197]
Blood pressure and brain blood flow. In anaesthetized cats, Selank into a vein lowered blood pressure by 32% for 1–3 minutes and raised brain blood flow by 24%. The paper prints the dose as 300 mg/kg, probably meaning mcg/kg. [125]
Where it goes and what it becomes. In rats, Selank was broken down in blood into shorter pieces (TKPRP, TKP and two-amino-acid fragments), and the intact peptide spread to the liver, kidneys and heart. [93], [91]

How this guide was researched

This guide is built from a thorough review of the sources cited throughout it: published scientific studies, official Russian product labels, regulatory documents and published protocol descriptions. We also reviewed public online forums, Russian review sites and community education groups where people describe their own experiences with Selank.

The guide cites 197 sources, including 60 original scientific papers. Each type of source answers a different question. Studies show what researchers measured. Labels show how the licensed product is meant to be used. Protocol descriptions show how Selank is typically used online. Personal accounts show what individual people experienced. Every numbered citation links to its entry below, labeled by source type.

How this guide was made

Research and drafting were AI-assisted. Every cited source was checked against the original, and the guide was reviewed and edited by Doserly before publication. It has not had an independent clinical review, and Doserly does not currently have medical reviewers. Doserly makes a medication and health-tracking app and runs Doserly Academy, both of which are promoted in this guide. Read our editorial policy for how guides are researched, updated and corrected.

This guide is for educational purposes. It summarizes what the reviewed sources report so the research is easier to understand; it is not medical advice. For a deeper dive, or to check any point for yourself, go straight to the cited sources.

Explore the sources

These are the documents cited in this guide. Studies, product labels, website advice and personal accounts answer different questions. A source being listed does not mean every statement on its page is endorsed.

Evidence typeFind in sources

Showing 197 sources

01
Selank 0.15% nasal drops (Селанк, капли назальные): instructions for medical use, registration ЛП-№(010951)-(РГ-RU) ↗
Peptogen; reproduced by the RLS drug encyclopedia · Last changed 15 Jul 2025
Official product label
Full text reviewed in Russian: uses, dose, course, contraindications (under 18, pregnancy, breastfeeding), side effects, interactions, driving and storage (15 days after opening).
02
Selank becomes a non-prescription medicine (Селанк стал безрецептурным препаратом) ↗
Peptogen (manufacturer news) · 2 Aug 2017
Manufacturer statement
Announcement reviewed in Russian: Ministry of Health decision moving Selank to non-prescription sale.
03
SELANK: substance record (UNII TS9JR8EP1G) ↗
US FDA Global Substance Registration System · Checked 24 Sep 2026
Chemical database
Record reviewed: sequence, identifiers and names. A substance record is not an approval.
04
Selank (compound record, CID 11765600) ↗
PubChem, US National Library of Medicine · Checked 24 Sep 2026
Chemical database
Record reviewed: formula C33H57N11O9 and molar mass 751.9 g/mol for the free peptide.
05
State Register of Medicines: Selank, registration ЛСР-003338/09 ↗
Ministry of Health of the Russian Federation · Registered 30 Apr 2009
Regulatory source
Registry entry reviewed: holder, dosage form (0.15% nasal drops), non-prescription status and substance registration.
06
Anxiolytic agent and pharmaceutical composition (patent RU 2155065 C1) ↗
Institute of Molecular Genetics RAS and Institute of Pharmacology RAMS · Filed 1999; published 27 Aug 2000
Patent
Full text reviewed in Russian: Selank drop formulation and anxiety use; states no toxicity at 200 or more times the therapeutic dose without data.
07
Tuftsin - Properties and Analogs ↗
Siebert A, Gensicka-Kowalewska M, Cholewinski G et al. · Curr Med Chem · 2017
Review
Original abstract reviewed.
08
Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks ↗
US FDA · content current as of 2026-04-22
Regulatory source
Page reviewed: "Selank acetate (TP-7)" listed as nominated but withdrawn, with concerns about immune reactions from aggregation and impurities and missing human safety information.
09
Drug Product Database search: Selank ↗
Health Canada · Checked 24 Sep 2026
Regulatory source
Search reviewed: no authorized Selank product.
10
Australian Register of Therapeutic Goods search: Selank ↗
Therapeutic Goods Administration · Checked 24 Sep 2026
Regulatory source
Search reviewed: no Selank product listed.
11
MHRA Products search: Selank ↗
Medicines and Healthcare products Regulatory Agency (UK) · Checked 24 Sep 2026
Regulatory source
Search reviewed: no results.
12
Medicines report: all medicines on the EMA website ↗
European Medicines Agency · Generated 24 Sep 2026
Regulatory source
Full list reviewed: no Selank product authorized, refused or withdrawn centrally. National authorizations were not checked.
13
Agent for prevention and treatment of viral diseases (patent RU 2337703 C1) ↗
Institute of Molecular Genetics RAS · Published 10 Nov 2008
Patent
Full text reviewed in Russian: antiviral use claimed from cell and mouse data.
14
Selank as a liver-protective agent (patents RU 2629832 C1 and RU 2640133 C1) ↗
Rospatent · Published 2017
Patent
Full texts reviewed in Russian: liver-protective use claimed from rat stress models.
15
Selank: original instructions for use (registration ЛСР-003338/09) ↗
Manufacturer instruction reproduced by Medvestnik · 2009 registration (undated copy)
Official product label
Full text reviewed in Russian. Superseded: single doses of 300–900 mcg, 900–2,700 mcg a day, and 1 drop = 0.05 mL = 75 mcg.
16
Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia ↗
Zozulia AA, Neznamov GG, Siuniakov TS et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2008
Human study
Full text reviewed in Russian (the abridged version hosted by the manufacturer on selank.ru). Its methods assign 42 patients to Selank and 20 to medazepam; the 30 and 32 in the English abstract are the diagnosis groups (generalized anxiety disorder and neurasthenia).
17
A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders ↗
Medvedev VE, Tereshchenko ON, Israelian AIu et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2014
Human study
Selected original full-text sections reviewed.
18
Optimization of the treatment of anxiety disorders with selank ↗
Medvedev VE, Tereshchenko ON, Kost NV et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2015
Human study
Selected original full-text sections reviewed.
19
American Wellness Pharmacy (AWP): Selank dosing page ↗
American Wellness Pharmacy (AWP) · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
20
DosingCalc: Selank dosing page ↗
DosingCalc · Page checked 24 Sep 2026 · Updated May 15, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
21
Peptide Dosing Protocols: Selank dosing page ↗
Peptide Dosing Protocols · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
22
PeptideCalcHub: Selank dosing page ↗
PeptideCalcHub · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
23
Middleway Nutrition: Selank dosing page ↗
Middleway Nutrition · Page checked 24 Sep 2026 · Updated July 22, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
24
PeptaBase: Selank dosing page ↗
PeptaBase · Page checked 24 Sep 2026 · Updated: September 4, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
25
PeptideDeck: Selank dosing page ↗
PeptideDeck · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
26
PeptideFox: Selank dosing page ↗
PeptideFox · Page checked 24 Sep 2026 · 2024-05-12 (page date string)
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
27
PepGuru: Selank dosing page ↗
PepGuru · Page checked 24 Sep 2026 · Last reviewed September 22, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
28
PeptideDosage.org: Selank dosing page ↗
PeptideDosage.org · Page checked 24 Sep 2026 · Last reviewed May 21, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
29
Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank ↗
Doyno CR, White CM · J Clin Pharmacol · 2021
Review
Original abstract reviewed.
30
Using Selank and/or Semax to get off SSRIS ↗
Reddit · r/Semax · Thread: 15 Jul 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
31
The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind ↗
Vanhee C, Francotte A, Janvier S et al. · Drug Test Anal · 2020
Regulatory source
Original abstract reviewed.
32
Peptide Schedule: Selank dosing page ↗
Peptide Schedule · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
33
ParaHealth: Selank dosing page ↗
ParaHealth · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
34
Peptide Initiative (protocol-dosing): Selank dosing page ↗
Peptide Initiative (protocol-dosing) · Page checked 24 Sep 2026 · Last updated: Sep 16, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
35
The Peptide Catalog: Selank dosing page ↗
The Peptide Catalog · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
36
Selank: instructions for medical use (ЛСР-003338/09), 2017 version ↗
Peptogen (manufacturer PDF) · 2 Aug 2017
Official product label
Full text reviewed in Russian: acetate form, dose, clearing the nose before dosing, storage.
37
Selank 0.15% nasal drops (Селанк): drug reference entry ↗
Vidal Russia · Monograph text 22 Oct 2018; registration line 15 Jul 2025
Official product label
Full entry reviewed in Russian; repeats the label's unsourced absorption figures and advises clearing the nose first.
38
Selank, an original peptide anxiolytic: information materials (Селанк — оригинальный пептидный анксиолитик) ↗
Neznamov GG et al., Zakusov Institute of Pharmacology; manufacturer-hosted booklet · Undated (about 2009–2012)
Developer summary
Full text reviewed in Russian: summaries of the clinical and animal studies, drop volume and unpublished toxicity testing. Written by the developers.
39
Neuropsychological disorders in tremor-dominant Parkinson's disease and essential tremor: correction with Selank ↗
Myasoedov NF et al. · Poliklinika · 2013
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 1,350 mcg a day for 3 weeks; no comparison group.
40
PeptidesExplorer: Selank dosing page ↗
PeptidesExplorer · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
41
The Peptide Guide (blend): Selank dosing page ↗
The Peptide Guide (blend) · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
42
Selank is life changing ↗
Reddit · r/Peptides · Thread: 24 Nov 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
43
Selank has changed my life. - is there a risk of tolerance / addiction ↗
Reddit · r/Peptides · Thread: 19 Nov 2024
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
44
Selank Vs SSRI. Want to switch from Seroxat to Selank. ↗
Reddit · r/Nootropics · Thread: 2 Aug 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
45
Clinical guideline: generalized anxiety disorder (Клинические рекомендации, ID 457) ↗
Russian Society of Psychiatrists; Ministry of Health of the Russian Federation · 2024
Clinical guideline
Full text reviewed in Russian: Selank is not mentioned.
46
Selank has been a game changer ↗
Reddit · r/Peptides · Thread: 28 May 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
47
Selank: The Solution to Anxiety Before Bed & Racing Thoughts? ↗
Substack newsletter · Undated
Public community
Post reviewed. A personal account and opinion, not a clinical outcome.
48
Selankkk made me more anxious ↗
Reddit · r/Selank · Thread: 10 Sep 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
49
First time Selank Experience Subq ↗
Reddit · r/Selank · Thread: 7 Aug 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
50
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 4 Sep 2019
Public community
Public review read in the original language. A personal account, not a clinical outcome.
51
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 24 Oct 2021
Public community
Public review read in the original language. A personal account, not a clinical outcome.
52
Results of a clinical-pharmacological study of the peptide anxiolytic Selank ↗
Teleshova ES et al. · Psikhiatriya (conference materials) · 2010
Human study
Full text reviewed in Russian (manufacturer-hosted copy): open pilot, 15 people aged 54–76.
53
New possibilities for enhancing SSRI action with the regulatory peptide Selank in anxiety-depressive disorders ↗
Verbenko VA et al. · Vrach · 2019
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 35 on escitalopram plus Selank versus 20 on escitalopram alone, 14 days.
54
Efficacy of peptide anxiolytic selank during modeling of withdrawal syndrome in rats with stable alcoholic motivation ↗
Kolik LG, Nadorova AV, Kozlovskaya MM · Bull Exp Biol Med · 2014
Animal study
Original abstract reviewed.
55
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats ↗
Konstantinopolsky MA, Chernyakova IV, Kolik LG · Bull Exp Biol Med · 2022
Animal study
Original abstract reviewed.
56
Benzo and selank ↗
Reddit · r/Selank · Thread: 5 Mar 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
57
Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank ↗
Kolomin T, Shadrina M, Andreeva L et al. · Regul Pept · 2011
Animal study
Original abstract reviewed.
58
The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress ↗
Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA et al. · Curr Rev Clin Exp Pharmacol · 2021
Animal study
Original abstract reviewed.
59
Antiviral activity of immunomodulator Selank in experimental influenza infection ↗
Ershov FI, Uchakin PN, Uchakina ON et al. · Vopr Virusol · 2009
Animal study
Original abstract reviewed.
60
Immunomodulatory effects of selank in patients with anxiety-asthenic disorders ↗
Uchakina ON, Uchakin PN, Miasoedov NF et al. · Zh Nevrol Psikhiatr Im S S Korsakova · 2008
Human study
Original abstract reviewed.
61
Intranasal Selank 0.15% for psychopharmacological correction in the combined treatment of bronchial asthma ↗
Beloglazov VA et al. · Poliklinika · 2019
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 40 with Selank versus 30 without.
62
The regulatory polypeptide Selank and combined phototherapy to improve treatment of atopic dermatitis ↗
Dontsova EV et al. · Vrach · 2020
Human study
Full text reviewed in Russian: four treatment groups, 124 patients.
63
Post-COVID syndrome: treating asthenic disorders with Selank ↗
Pogodina MG et al. · Vrach · 2024
Human study
Original abstract reviewed: 32 with Selank plus other treatment versus 32 without, 30 days; assignment not stated.
64
Selank is absolutely amazing as someone suffering from PTSD ↗
Reddit · r/Selank · Thread: 23 Dec 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
65
Should I do Semax, Selank or both? ↗
Reddit · r/Nootropics · Thread: 29 Jun 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
66
Headache syndrome and approaches to relieving it in patients of different ages at the sanatorium stage ↗
Zavadskaya et al. · Vrach · 2020
Human study
Full text reviewed in Russian: 20 with Selank versus 20 without; counts 4 drops as 150 mcg.
67
Pure Tested Peptides: Selank dosing page ↗
Pure Tested Peptides · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
68
Know Your Peptide: Selank dosing page ↗
Know Your Peptide · Page checked 24 Sep 2026 · Published April 10, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
69
PeptiTools: Selank dosing page ↗
PeptiTools · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
70
FormBlends (DIY spray guide): Selank dosing page ↗
FormBlends (DIY spray guide) · Page checked 24 Sep 2026 · Updated May 30, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
71
COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE ↗
Vasil'eva EV, Kondrakhin EA, Salimov RM et al. · Eksp Klin Farmakol · 2016
Animal study
Original abstract reviewed.
72
Selank is amazing at stabilizing mood ↗
Reddit · r/Nootropics · Thread: 14 Jul 2016
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
73
The Workout Mag: Selank dosing page ↗
The Workout Mag · Page checked 24 Sep 2026 · Published Sep 24, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
74
The new peptide anxiolytic Selank in the treatment of psychogenic overeating ↗
Verbenko VA et al. · Klinicheskaya psikhiatriya · 2016
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 15 with Selank versus 15 controls.
75
Possibilities of cognitive-affective disorders correction in patients with atopic dermatitis using selanc regulatory peptide (Kruglova LS, Novikova LA, Dontsova EV, Borzunova LN) ↗
Kruglova LS et al. · Chelovek i ego zdorovye (Kursk) · 2020
Human study
Original abstract reviewed.
76
Selank experience and review ↗
Reddit · r/Peptides · Thread: 25 Jan 2021
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
77
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 9 Dec 2021
Public community
Public review read in the original language. A personal account, not a clinical outcome.
78
Selank cycling? ↗
Reddit · r/Selank · Thread: 13 May 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
79
What does selank feel like ↗
Reddit · r/Peptides · Thread: 17 Apr 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
80
Peptide Initiative (protocols): Selank dosing page ↗
Peptide Initiative (protocols) · Page checked 24 Sep 2026 · Last updated: Sep 16, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
81
All About Peptides: Selank dosing page ↗
All About Peptides · Page checked 24 Sep 2026 · Updated October 29, 2025
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
82
Peptide Dosages: Selank dosing page ↗
Peptide Dosages · Page checked 24 Sep 2026 · Published March 1, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
83
Selank Co (clinical trials): Selank dosing page ↗
Selank Co (clinical trials) · Page checked 24 Sep 2026 · 2026-07-26
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
84
Peptides.ID: Selank dosing page ↗
Peptides.ID · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
85
Guide to Peptide: Selank dosing page ↗
Guide to Peptide · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
86
BHR Center: Selank dosing page ↗
BHR Center · Page checked 24 Sep 2026 · Published: August 11, 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
87
The Peptide Guides (stack): Selank dosing page ↗
The Peptide Guides (stack) · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
88
ClinicalTrials.gov searches: selank, Селанк, TKPRPGP ↗
US National Library of Medicine · Checked 24 Sep 2026
Study registry
Searches reviewed: no Selank study registered.
89
WHO International Clinical Trials Registry Platform search: selank ↗
World Health Organization · Checked 24 Sep 2026
Study registry
Search reviewed: no Selank study registered.
90
Register of clinical-trial permits: Selank ↗
Ministry of Health of the Russian Federation (State Register) · Checked 24 Sep 2026
Study registry
Register reviewed: two 2004 permits (Nos. 178 and 179) with protocol, phase and patient numbers blank.
91
The pharmacokinetics and metabolism of heptapeptide--a prospective synthetic analog of tuftsin with psychostimulating action in rats ↗
Boĭko SS, Zherdev VP, Dvorianinov AA et al. · Eksp Klin Farmakol · 1998
Animal study
Original abstract reviewed.
92
A comparative analysis of distribution of glyprolines administered by various routes ↗
Ashmarin IP, Baglikova KE, Edeeva SE et al. · Bioorg Khim · 2008
Animal study
Original abstract reviewed.
93
Evenly tritium-labeled peptides and their in vivo and in vitro biodegradation ↗
Zolotarev IuA, Dadaian AK, Dolotov OV et al. · Bioorg Khim · 2006
Animal study
Original abstract reviewed.
94
Selank, nasal spray con? ↗
Reddit · r/Selank · Thread: 26 Jul 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
95
My Experience with Selank Nasal Spray (One-Sided Reaction) ↗
Reddit · r/Selank · Thread: 23 Apr 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
96
N-Acetyl Selank Nasal Spray Caused Bad Trip Like Experience ↗
Reddit · r/Nootropics · Thread: 8 Sep 2021
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
97
NA-Selank Ruined My Brain ↗
Reddit · r/Nootropics · Thread: 9 Dec 2021
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
98
Natural and hybrid ("chimeric") stable regulatory glyproline peptides ↗
Ashmarin IP, Samonina GE, Lyapina LA et al. · Pathophysiology · 2005
Review
Original abstract reviewed.
99
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 13 Nov 2017
Public community
Public review read in the original language. A personal account, not a clinical outcome.
100
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 3 Nov 2024
Public community
Public review read in the original language. A personal account, not a clinical outcome.
101
Rapid and slow response during treatment of generalized anxiety disorder with peptide anxiolytic Selank ↗
Syunyakov TS et al. · European Psychiatry (conference abstract P-1114) · 2012
Human study
Original abstract reviewed.
102
Selank: 42 reviews (Селанк - 42 отзыва) ↗
protabletky.ru, patient and doctor reviews · Undated
Public community
Reviews read in Russian, including doctors' comments. Personal accounts, not clinical outcomes.
103
selank for anxiety/panic? ↗
Reddit · r/Peptides · Thread: 28 Mar 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
104
Anxiety-relieving and stress-protective effects of Selank in adjustment disorder and post-traumatic stress ↗
Verbenko VA, Shakina AV · Manufacturer-hosted article · Year not printed
Human study
Full text reviewed in Russian: 30 with Selank versus 15 untreated controls.
105
Selank for autonomic and emotional disorders of the climacteric (menopause) syndrome ↗
Starikov et al. · Vrach · 2019
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 900 mcg a day for 14 days.
106
Selank in the treatment of lumbosacral pain ↗
Lalayan T, Korzhavina N · Vrach · About 2014
Human study
Full text reviewed in Russian (manufacturer-hosted copy): 32 patients, 1,350 mcg a day for 14 days.
107
Functional Connectomic Approach to Studying Selank and Semax Effects ↗
Panikratova YR, Lebedeva IS, Sokolov OY et al. · Dokl Biol Sci · 2020
Human study
Original abstract reviewed.
108
The anxiolytic action of an analog of the endogenous peptide tuftsin on inbred mice with different phenotypes of the emotional stress reaction ↗
Seredenin SB, Kozlovskaia MM, Blednov IuA et al. · Zh Vyssh Nerv Deiat Im I P Pavlova · 1998
Animal study
Original abstract reviewed.
109
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission ↗
Volkova A, Shadrina M, Kolomin T et al. · Front Pharmacol · 2016
Animal study
Selected original full-text sections reviewed.
110
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity ↗
Vyunova TV, Andreeva L, Shevchenko K et al. · Protein Pept Lett · 2018
Cell study
Original abstract reviewed.
111
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells ↗
Filatova E, Kasian A, Kolomin T et al. · Front Pharmacol · 2017
Cell study
Selected original full-text sections reviewed.
112
Peptidergic modulation of the hippocampus synaptic activity ↗
Skrebitskiĭ VG, Kondratenko RV, Povarov IS et al. · Ross Fiziol Zh Im I M Sechenova · 2011
Cell study
Original abstract reviewed.
113
Effect of Selank on Spontaneous Synaptic Activity of Rat Hippocampal CA1 Neurons ↗
Povarov IS, Kondratenko RV, Derevyagin VI et al. · Bull Exp Biol Med · 2017
Cell study
Original abstract reviewed.
114
Semax and selank inhibit the enkephalin-degrading enzymes from human serum ↗
Kost NV, Sokolov OIu, Gabaeva MV et al. · Bioorg Khim · 2001
Cell study
Original abstract reviewed.
115
The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity ↗
Zozulya AA, Kost NV, Yu Sokolov O et al. · Bull Exp Biol Med · 2001
Cell study
Original abstract reviewed.
116
The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank ↗
Kozlovskiĭ II, Andreeva LA, Kozlovskaia MM et al. · Eksp Klin Farmakol · 2012
Animal study
Original abstract reviewed.
117
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioral manifestations of hyperfunction of dopamine system ↗
Meshavkin VK, Kost NV, Sokolov OY et al. · Bull Exp Biol Med · 2006
Animal study
Original abstract reviewed.
118
Effects of heptapeptide selank on the content of monoamines and their metabolites in the brain of BALB/C and C57Bl/6 mice: a comparative study ↗
Narkevich VB, Kudrin VS, Klodt PM et al. · Eksp Klin Farmakol · 2008
Animal study
Original abstract reviewed.
119
Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA ↗
Semenova TP, kozlovskiĭ II, Zakharova NM et al. · Eksp Klin Farmakol · 2009
Animal study
Original abstract reviewed.
120
Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo ↗
Inozemtseva LS, Karpenko EA, Dolotov OV et al. · Dokl Biol Sci · 2008
Animal study
Title and index record reviewed; no abstract or full text available.
121
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats ↗
Kolik LG, Nadorova AV, Antipova TA et al. · Bull Exp Biol Med · 2019
Animal study
Original abstract reviewed.
122
Anticoagulant Effects of Arginine-Containing Peptides of the Glyproline Family (His-Phe-Arg-Trp-Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro) Revealed by Thromboelastography ↗
Rogozinskaya EY, Lyapina MG · Bull Exp Biol Med · 2017
Cell study
Original abstract reviewed.
123
PB480: The Effect of Peptide Selank on the Parameters of the Rat Hemostasis System against the Background of Endothelial Dysfunction (Rogozinskaya E, Lyapina L) ↗
Research and Practice in Thrombosis and Haemostasis (congress abstract PB480) · 2018
Animal study
Selected original full-text sections reviewed.
124
The role of the tuftsin and Selank peptides in the regulation of primary and plasma homeostasis (Lyapina LA, Grigorieva ME, Obergan TYu, Maistrenko ES) ↗
Lyapina LA et al. · Biology Bulletin · 2017
Animal study
Original abstract reviewed.
125
Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats ↗
Gan'shina TS, Kozlovskiĭ II · Eksp Klin Farmakol · 2005
Animal study
Original abstract reviewed.
126
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 17 Dec 2021
Public community
Public review read in the original language. A personal account, not a clinical outcome.
127
Taking Selank everyday, any risks? ↗
Reddit · r/Nootropics · Thread: 6 Sep 2017
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
128
Irritable? ↗
Reddit · r/Selank · Thread: 25 Oct 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
129
Just started selank, 250 mcg. twice daily. it seems to make me very irritable. Anybody else experience this? ↗
Reddit · r/Selank · Thread: 29 Sep 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
130
Selank question ↗
Reddit · r/Selank · Thread: 10 Jan 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
131
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 27 Mar 2020
Public community
Public review read in the original language. A personal account, not a clinical outcome.
132
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 26 Jun 2026
Public community
Public review read in the original language. A personal account, not a clinical outcome.
133
Has Selank made anyone too content, to the point of having no interest in anything? ↗
Reddit · r/Nootropics · Thread: 5 Jan 2022
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
134
Selank sides ↗
Reddit · r/Peptides · Thread: 12 Mar 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
135
Selank review ↗
Longecity forum · Thread 2014–2018
Public community
Public review read in the original language. A personal account, not a clinical outcome.
136
My experience with using Selank for 20 days. ↗
Reddit · r/Selank · Thread: 19 Aug 2024
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
137
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 5 Apr 2020
Public community
Public review read in the original language. A personal account, not a clinical outcome.
138
Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight ↗
Czabak-Garbacz R, Cygan B, Wolański L et al. · Pharmacol Rep · 2006
Animal study
Original abstract reviewed.
139
Selank - Take continuously or cycle? ↗
Reddit · r/Nootropics · Thread: 14 Sep 2019
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
140
Selank is great for social anxiety ↗
Reddit · r/Nootropics · Thread: 23 Oct 2017
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
141
23M - is it possible to undo balding induced by BDNF peptides like Semax / Selank? ↗
Reddit · r/Nootropics · Thread: 11 Jun 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
142
Semax/Selank and intense hair loss ↗
Reddit · r/Nootropics · Thread: 30 Oct 2016
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
143
Is Selank supposed to be blue? ↗
Reddit · r/Selank · Thread: 26 Aug 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
144
Bulk Drug Substances Used in Compounding ↗
US FDA · Content current as of 26 Mar 2026
Regulatory source
Selected original full-text sections reviewed.
145
Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (categories list) ↗
US FDA · Updated 14 May 2026
Regulatory source
Full list reviewed: Selank is in no category.
146
So grateful for selank ↗
Reddit · r/Selank · Thread: 7 Jul 2026
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
147
FDA has banned 17 peptides inuding Dihexa, Semax, Selank, Epitalon, Bpc-157 ↗
Reddit · r/Nootropics · Thread: 9 Jun 2024
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
148
Federal Register search: selank ↗
Federal Register · Checked 24 Sep 2026
Regulatory source
Search reviewed: no document names Selank.
149
Electronic Code of Federal Regulations search: selank ↗
eCFR · Checked 24 Sep 2026
Regulatory source
Search reviewed: no regulation names Selank.
150
Unauthorized injectable peptide drugs seized from Optimum Wellness Centre, Calgary (RA-77218) ↗
Health Canada · 1 Apr 2025
Regulatory source
Advisory reviewed; names Selank among unauthorized injectable products seized from a clinic.
151
Unauthorized injectable peptide drugs seized and sold by Canada Peptide may pose serious health risks (RA-77807) ↗
Health Canada · 1 Aug 2025
Regulatory source
Advisory reviewed; names Selank among unauthorized injectable products seized from an online seller.
152
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 (F2026L00633) ↗
Australian Government, Federal Register of Legislation · Made 27 May 2026
Regulatory source
Full instrument searched: Selank is not named.
153
TGA warning on the risks of importing unapproved peptide products ↗
Therapeutic Goods Administration (Australia) · 7 May 2026
Regulatory source
Selected original full-text sections reviewed.
154
Selank: Ukrainian instructions and registration UA/11687/01/01 ↗
Copy of the Ukrainian State Register entry (LikiControl) · Registration expired 30 Aug 2016
Official product label
Full text reviewed in Ukrainian: prescription-only registration, now expired.
155
State Register of Medicinal Products of Ukraine: search for Selank ↗
Ministry of Health of Ukraine · Checked 24 Sep 2026
Regulatory source
Name search and full register file reviewed: no current Selank product.
156
World Anti-Doping Code International Standard: Prohibited List 2026 ↗
World Anti-Doping Agency · 2026
Regulatory source
Full list reviewed: Selank not named; S0 covers substances with no current government approval for human use.
157
World Anti-Doping Code International Standard: Prohibited List 2027 ↗
World Anti-Doping Agency · Published 26 Aug 2026
Regulatory source
Full list reviewed: Selank not named.
158
"Brain doping" substances: prohibited or not in sports? (Pokrywka A et al.; Polish Anti-Doping Agency scientific team) ↗
Pokrywka A et al. (Polish Anti-Doping Agency) · Biology of Sport · 2025
Review
Full text reviewed: lists Selank's anti-doping status as unclear.
159
Global DRO substance search: Selank ↗
Global Drug Reference Online (US) · Checked 24 Sep 2026
Regulatory source
Search reviewed: no Selank entry.
160
Research Chemicals: A Worrying Trend Putting Athletes at Risk ↗
U.S. Anti-Doping Agency · Updated 27 Feb 2026
Regulatory source
Selected original full-text sections reviewed.
161
I consumed large amounts of Semax, Selank, and P21 intranasally between the ages of 12 and 14. ↗
Reddit · r/Nootropics · Thread: 17 Jan 2021
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
162
Combined Action of Benzodiazepine Tranquilizers and Peptide Anxiolytic Selank in BALB/c Mice (Kost NV, Sokolov OYu, Zozulya SA, Myasoedov NF) ↗
Kost NV et al. · Neurochemical Journal · 2025
Animal study
Original abstract reviewed.
163
Selank and Delta-8 = Nightmare for me. ↗
Reddit · r/Peptides · Thread: 9 Feb 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
164
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 10 Aug 2020
Public community
Public review read in the original language. A personal account, not a clinical outcome.
165
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 1 Nov 2018
Public community
Public review read in the original language. A personal account, not a clinical outcome.
166
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 14 Apr 2017
Public community
Public review read in the original language. A personal account, not a clinical outcome.
167
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 23 Apr 2020
Public community
Public review read in the original language. A personal account, not a clinical outcome.
168
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 13 Feb 2019
Public community
Public review read in the original language. A personal account, not a clinical outcome.
169
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 25 Oct 2024
Public community
Public review read in the original language. A personal account, not a clinical outcome.
170
SELANK (product discussion thread) ↗
Longecity forum · Thread 2009–2010
Public community
Public review read in the original language. A personal account, not a clinical outcome.
171
Gorilla Healing Selank: No noticeable effects at all 200mcg 3times a day. ↗
Reddit · r/Peptides · Thread: 28 Mar 2023
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
172
2,5mg semax and 1mg selank = zero effect felt ↗
Reddit · r/Nootropics · Thread: 6 Sep 2025
Public community
Archived post and replies reviewed. Personal accounts, not clinical outcomes.
173
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 5 Aug 2019
Public community
Public review read in the original language. A personal account, not a clinical outcome.
174
Review of Selank 0.15% nasal drops (in Russian) ↗
Otzovik · 4 Feb 2022
Public community
Public review read in the original language. A personal account, not a clinical outcome.
175
FDA briefing document: Semax ↗
US FDA · Pharmacy Compounding Advisory Committee briefing · 2026
Regulatory source
Full document reviewed; notes US websites selling Semax combined with Selank, including a 50:50 injectable and nasal spray.
176
Semax 0.1% nasal drops (Семакс, капли назальные 0.1%): drug reference entry ↗
Vidal Russia · Registration of 26 Mar 2025
Official product label
Full entry reviewed in Russian: dosing by use, contraindications, side effects. Reproduces the official instructions.
177
Pharmacy Compounding Advisory Committee, 24 July 2026: Semax votes (official livestream) ↗
US FDA · 24 Jul 2026
Regulatory source
Official livestream captions reviewed: 8 yes, 5 no, 1 abstain for Semax free base and for Semax acetate. Captions, not certified minutes.
178
Characterization of a delta-electroencephalogram (-sleep)-inducing peptide ↗
Schoenenberger GA, Monnier M · PNAS · 1977
Animal study
Original abstract reviewed.
179
FDA briefing document: emideltide-related bulk drug substances ↗
US FDA · Pharmacy Compounding Advisory Committee briefing · 11 May 2026
Regulatory source
Full document reviewed: identity, FDA's summaries of the human studies, safety concerns and the staff recommendation.
180
Deltaran (Дельтаран): instructions for medical use, 2026 registration ↗
NIC KOMKON (registration holder) · Russian State Register of Medicines · 2026
Official product label
Full text read in Russian: composition, uses, dosing, storage, contraindications, bradycardia caution and non-prescription status.
181
Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs ↗
Monti JM et al. · International Journal of Clinical Pharmacology Research · 1987
Human trial (randomized, placebo, crossover)
Original abstract reviewed.
182
Pharmacy Compounding Advisory Committee, 24 July 2026: emideltide votes (official meeting recording) ↗
US FDA · Meeting webcast · 24 Jul 2026
Regulatory source
Voting segments reviewed from the recording's automatic captions: 6 yes, 7 no, 1 abstention for the free base and the same for the acetate. Not certified minutes. Later in the same recording, the Epitalon votes were 7 yes, 4 no and 1 abstention for each form.
183
Peptide Dosing Protocols (stack): Selank dosing page ↗
Peptide Dosing Protocols (stack) · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
184
PeptIQ: Selank dosing page ↗
PeptIQ · Page checked 24 Sep 2026
Dosing website
Original page reviewed 24 Sep 2026. Describes practice; not clinical validation.
185
Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions ↗
Sokolov OY, Meshavkin VK, Kost NV et al. · Bull Exp Biol Med · 2002
Animal study
Original abstract reviewed.
186
Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice ↗
Sarkisova KIu, Kozlovskiĭ II, Kozlovskaia MM · Zh Vyssh Nerv Deiat Im I P Pavlova · 2008
Animal study
Original abstract reviewed.
187
Compensatory and antiamnestic effects of heptapeptide Selank in monkeys ↗
· Zh Evol Biokhim Fiziol · 2008
Animal study
Original abstract reviewed.
188
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats ↗
Kasian A, Kolomin T, Andreeva L et al. · Behav Neurol · 2017
Animal study
Selected original full-text sections reviewed.
189
Optimizing action of synthetic peptide Selank on active avoidance conditioning test in rats ↗
Kozlovskiĭ II, Danchev ND · Zh Vyssh Nerv Deiat Im I P Pavlova · 2002
Animal study
Original abstract reviewed.
190
Experimental optimization of learning and memory processes by selank ↗
Semenova TP, Kozlovskiĭ II, Zakharova NM et al. · Eksp Klin Farmakol · 2010
Animal study
Original abstract reviewed.
191
Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny ↗
Semenova TP, Kozlovskaya MM, Zakharova NM et al. · Bull Exp Biol Med · 2007
Animal study
Original abstract reviewed.
192
Protective effect of selank on the model of mnestic function violation induced by pharmacological blockade of protein synthesis ↗
Kozlovskiĭ II, Belozertsev FIu, Andreeva LA et al. · Eksp Klin Farmakol · 2013
Animal study
Original abstract reviewed.
193
Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice ↗
Kolik LG, Nadorova AV, Seredenin SB · Bull Exp Biol Med · 2016
Animal study
Original abstract reviewed.
194
Transcriptome alteration in hippocampus under the treatment of tuftsin analog Selank ↗
Kolomin TA, Agapova TIu, Agniullin IaV et al. · Zh Vyssh Nerv Deiat Im I P Pavlova · 2013
Animal study
Original abstract reviewed.
195
Selank and its metabolites maintain homeostasis in the gastric mucosa ↗
Pavlov TS, Samonina GE, Bakaeva ZV et al. · Bull Exp Biol Med · 2007
Animal study
Original abstract reviewed.
196
Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress ↗
Fomenko EV, Bobyntsev II, Kryukov AA et al. · Bull Exp Biol Med · 2017
Animal study
Original abstract reviewed.
197
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells ↗
Kobylyanskii AG, Zolotarev YA, Andreeva LA et al. · Bull Exp Biol Med · 2017
Cell study
Original abstract reviewed.

Updates and corrections

Updated September 26, 2026. This is the first version of the guide in its new format. It replaces an earlier, shorter reference page with a full review of the Russian labels, the human trials, regulatory status, dosing sources and community experience, and adds sections on storage, what happens when people stop, what to monitor and how Selank compares with related peptides. Verified points from the earlier page were carried over. Corrections: the medazepam trial gave Selank to 42 patients and medazepam to 20 (the 30 and 32 in its summary are the diagnosis groups), and the anxiety trials used 2,700 mcg a day for 14 days, which the earlier page could not state. The phenazepam comparison is now described in full: phenazepam worked more strongly during treatment, and Selank had more responders a week after stopping. The earlier page said the label's drops could not be converted into micrograms; the original 2009 instruction gives 75 mcg per drop, so the label dose is about 900 mcg a day. Descriptions of Selank as working without sedation or dependence were narrowed, because dependence was never formally studied and some users report drowsiness. The date describes this revision, not a fresh check of every source.

Found an error or a relevant study we missed? Report a correction with the guide title, the specific passage and a supporting source if available. Please leave out personal health records. See our editorial policy for how we handle attribution, evidence limits and corrections.

About this guide

Disclaimer

Educational Purpose

This guide is for educational and informational purposes only. It is not medical advice and should not replace consultation with a licensed and qualified healthcare professional.

AI Content Disclosure

The Doserly Editorial Team makes every effort to ensure accuracy. This content may include AI-generated summaries and content with cited reference sources. AI tools can inherently make errors. Readers should verify claims independently using the cited sources.

Mixed Regulatory Status

This compound is approved in some forms or countries and sold as a research compound in others. Status depends on the formulation, use, and jurisdiction. Approval does not extend to other forms or uses; prescription treatment requires medical supervision.

Risk Acknowledgment

There are inherent risks involved with any compound, especially for individuals with underlying health conditions, unique family medical histories, or those currently taking other medications, supplements, or compounds that may interact. Always consult a healthcare provider before starting, changing, or stopping any protocol.

Product Neutrality

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